Prediction of Early Recanalization after Intravenous Thrombolysis in Patients with Large-Vessel Occlusion.

"Disclosure: The authors have no financial conflicts of interest."

"This work was supported by a grant from the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2018R1A2A3074996); a faculty research grant of Yonsei University College of Medicine (6-2020-0202); and the “Dongwha” Faculty Research Assistance Program of Yonsei University College of Medicine (6-2019-0191)."

"For the validation cohort, we used data from the Selection Criteria in Endovascular Thrombectomy and Thrombolytic Therapy (SECRET) registry (Clinicaltrials.gov: NCT02964052) []. The SECRET registry is a nationwide multicenter registry for exploring the selection criteria for patients who would benefit from reperfusion therapies. This study included 1,026 patients who had been registered retrospectively from 15 hospitals between January 2012 and December 2015 and 333 patients who had been registered prospectively from 13 hospitals between November 2016 and December 2017. There were 98 patients with visible thrombi in the distal ICA and/or MCA on initial thin-section NCCT and those with imaging data available before and after IV t-PA. However, there was an overlap of the study period between the Thrombus Imaging Study and the SECRET study. Therefore, we excluded 22 patients (anonymized) who were enrolled during the overlapped period. Finally, 76 patients were included for the validation (). This study was approved by the Institutional Review Board of each study hospital, and written informed consent was obtained from all patients enrolled prospectively."