Upadacitinib Treatment Improves Symptoms of Bowel Urgency and Abdominal Pain, and Correlates With Quality of Life Improvements in Patients With Moderate to Severe Ulcerative Colitis.

"Conflict of Interest SG received lecture fee[s] from AbbVie, Janssen, Takeda, Pfizer, Celltrion, Eli Lilly, Shield, Ferring, Falk Pharma; is steering/advisory committee member for Pfizer, Janssen, AbbVie, Bristol Myers Squibb, Celgene, Boehringer Ingelheim, Celltrion, Gilead, Galapagos, Eli Lilly, Takeda; and received research support from GSK, AbbVie, and Vertex. YSG, WZ, RC, and WX are AbbVie employees and may own AbbVie stock/stock options. EL received financial support for research from Takeda, Pfizer, and Janssen; received lecture fee[s] from AbbVie, Celgene, Falk, Ferring, MSD, Takeda, Janssen, and Pfizer; received consultancy fees from AbbVie; received educational grants from AbbVie, Takeda, and Janssen; and served on advisory boards for AbbVie, Ferring, MSD, Takeda, Celgene, Janssen, Gilead-Galapagos, Arena, Pfizer, and Eli Lilly. EVL Jr received financial support for research from AbbVie, Takeda, Janssen, UCB, Amgen, Pfizer, Genentech, Gilead, Celgene, Robarts Clinical Trials, Receptos, Bristol Myers Squibb, Theravance; and received consultancy fees from AbbVie, Allergan, Boehringer Ingelheim, Takeda, Janssen, UCB, Amgen, Pfizer, Eli Lilly, Celgene, Celltrion Healthcare, Bristol Myers Squibb, Gilead, Genentech, Iterative Scopes, Ono Pharma, Calibr, Arena, and Sun Pharma. JP received financial support for research from AbbVie and Pfizer; received lecture fee[s] from AbbVie, Ferring, Janssen, and Takeda; and received consultancy fees from AbbVie, Arena Pharmaceuticals, Boehringer Ingelheim, Celgene, Celltrion, Ferring, Genentech, Janssen, Origo, Pandion, Pfizer, Robarts, Roche, Second Genome, Takeda, Theravance, and Wassermann. SD received speaker fees from Ferring, Merck Sharp & Dohme, and UCB Pharma; received consulting fees from Abbott Laboratories, AbbVie, AstraZeneca, Schering Plough, Takeda, and Millennium; and served as board member of Merck Sharp & Dohme."

"Funding This work was supported by AbbVie Inc. AbbVie sponsored the study; contributed to the design; and participated in collection, analysis, and interpretation of data and in writing, reviewing, and approval of the final version. No honoraria or payments were made for authorship."