Lack of predictive tools for conventional and targeted cancer therapy: Barriers to biomarker development and clinical translation.

"Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper."

"AcknowledgementsKP acknowledges funding from CRUK (grant ID: C11497/A28789).We acknowledge funding from Cancer Research UK (grant ID: CRUK/13/026; grant ID: CRUK-A12617) and MRC (grant ID: MR/S005498/1).We would like to thank Queen Elizabeth Hospital Birmingham Charity and The Get A-head Charitable Trust for their continuous support (grant ID: 16/5/741).Professor Mehanna is a National Institute for Health Research (NIHR) Senior Investigator. The views expressed in this article are those of the author(s) and not necessarily those of the NIHR, or the Department of Health and Social Care."