AF10 (MLLT10) prevents somatic cell reprogramming through regulation of DOT1L-mediated H3K79 methylation.

"rna-sequencing data are deposited to the ncbi geo database with the accession number gse161043.; availability of data and materials rna-sequencing data are deposited to the ncbi geo database with the accession number gse161043. raw data from lc-ms/ms analysis can be found in additional file 4 availability of data and materials rna-sequencing data are deposited to the ncbi geo database with the accession number gse161043"

"Declarations Ethics approval and consent to participateNot applicable. Consent for publicationNot applicable. Competing interestsThe authors declare no competing interests. Competing interests The authors declare no competing interests."

"Funding This work was supported by EMBO Installation Grant (TO), Newton Advanced Fellowship (T.O.), TUBITAK Project 115Z706 (T.O.), Arthritis Research UK (program Grant 20522, UO), Cancer Research UK (UO) and the LEAN project of the Leducq Foundation (UO). The research leading to these results has received funding from the People Programme (Marie Curie Actions) of the European Union’s Seventh Framework Programme (FP7/2007–2013) under REA Grant agreement no. [609305]."