Corporations, high-stakes biomedical research, and research misconduct: yes they can (and sometimes do).

Authors:
Morreim EH.

Journal:
J Law Biosci

Publication Year: 2021

DOI:
10.1093/jlb/lsab014

PMCID:
PMC8247552

PMID:
34221435

Journal Information

Full Title: J Law Biosci

Abbreviation: J Law Biosci

Country: Unknown

Publisher: Unknown

Language: N/A

Publication Details

Subject Category: Medical Ethics

Available in Europe PMC: Yes

Available in PMC: Yes

PDF Available: No

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3/6
50.0% Transparent
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Evidence found in paper:

"CONFLICT OF INTEREST The author filed one report and one declaration as an expert on behalf of Plaintiff CrossFit, Inc. in Part IV’s final case study. Holman & Elliott, supra note 19, at 4 (Design bias ‘occurs when companies shape science by designing studies in ways that are most likely to generate results that are favorable to them …. Researchers can give a competitor’s drug in an overly high dose to make their drug look safe by comparison or in a low dose to make theirs look more effective. They can also selectively report outcomes or positive subgroups, secondary analyses, or post hoc analyses as if they were always the intended focus of the paper.’). See M. Wynia & D. Boren, Better Regulation of Industry-Sponsored Clinical Trials is Long Overdue , 37 J.L., Med & Ethics 410, 410–19 (2009); M. Angell, Industry-Sponsored Clinical Research: A Broken System , 300 JAMA 1069, 1070 (2008); M. Gaudino et al, Characteristics of Contemporary Randomized Clinical Trials and Their Association With the Trial Funding Source in Invasive Cardiovascular Interventions , JAMA Internal   Med . (June 1, 2020); R. Smith, Medical Journals are an Extension of the Marketing Arm of Pharmaceutical Companies , 2 P Lo S Med . 0364, 0365 (2005), https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.0020138; see also M.A. Rodwin, Conflicts of Interest, Institutional Corruption, and Pharma: An Agenda for Reform , 40 J.L., Med. & Ethics 511, 513 (2012); Sismondo, supra note 27, at 60."

Evidence found in paper:

"Holman & Elliott, supra note 19, at 4 (Design bias ‘occurs when companies shape science by designing studies in ways that are most likely to generate results that are favorable to them …. Researchers can give a competitor’s drug in an overly high dose to make their drug look safe by comparison or in a low dose to make theirs look more effective. They can also selectively report outcomes or positive subgroups, secondary analyses, or post hoc analyses as if they were always the intended focus of the paper.’). See M. Wynia & D. Boren, Better Regulation of Industry-Sponsored Clinical Trials is Long Overdue , 37 J.L., Med & Ethics 410, 410–19 (2009); M. Angell, Industry-Sponsored Clinical Research: A Broken System , 300 JAMA 1069, 1070 (2008); M. Gaudino et al, Characteristics of Contemporary Randomized Clinical Trials and Their Association With the Trial Funding Source in Invasive Cardiovascular Interventions , JAMA Internal   Med . (June 1, 2020); R. Smith, Medical Journals are an Extension of the Marketing Arm of Pharmaceutical Companies , 2 P Lo S Med . 0364, 0365 (2005), https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.0020138; see also M.A. Rodwin, Conflicts of Interest, Institutional Corruption, and Pharma: An Agenda for Reform , 40 J.L., Med. & Ethics 511, 513 (2012); Sismondo, supra note 27, at 60."

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Last Updated: Aug 05, 2025