Mitochondrial calcium uniporter deletion prevents painful diabetic neuropathy by restoring mitochondrial morphology and dynamics.

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"This work was supported by NIH R01 and NIH HEAL initiative supplement R01 NS104295-01, NIH/NIAMS R01 AR077691-01 (D.M.M.) and NIH and NIH/Rush University Medical Center 1R01AR064251-01 (R.J.M., A.M.M.). Jeffery Savas laboratory is supported in part by AG061787. The authors thank Dr. Rajeshwar Awatramani for helpful discussions. The authors thank Dr. Shingo Ishihara for the technical assistance with the paw hyperalgesia experiments and Dr. Vania Apkarian's lab and Maria Virginia Centeno for allowing us to use the Ugo Basile apparatus. The authors thank Lennell Reynolds Jr at the Northwestern University Center for Advanced Microscopy for help with the electron microscope. The authors thank Dr. Jeffery Molkentin (Cincinnati Children's Hospital Medical Center) for the generous gift of the MCUfl/fl mice."