Prophylactic corticosteroid use in patients receiving axicabtagene ciloleucel for large B-cell lymphoma.

"additional inclusion/exclusion criteria are available in data s1 .; bridging therapy was allowed per investigator discretion (e g patients with bulky or rapidly progressing disease at baseline) after leukapheresis (data s1 ).; secondary end-points included investigator-assessed orr (cr plus partial response) per revised international working group response criteria for malignant lymphoma duration of response (dor) progression-free survival (pfs) overall survival (os) incidence of aes and levels of anti-cd19 car-t cells and cytokines in blood (data s1 ).; exploratory end-points included biomarker assessments (data s1 ).; exploratory retrospective psm analysis was performed to descriptively compare results for cohort 6 and cohorts1 + 2 (primary analysis) after balancing for the following key baseline disease characteristics: tumour burden international prognostic index score number of prior lines of chemotherapy disease stage and lactate dehydrogenase level (data s1 ).; data s1 ."

"Conflict of interest OOO: consultancy or advisory role for Kite, a Gilead Company, Pfizer, Spectrum Pharmaceuticals, Legend, and Bayer. KB: honoraria from Kite, a Gilead Company, Takeda, Roche, and Celgene; consultancy or advisory role for Kite, a Gilead Company, Takeda, Roche, and Sandoz; travel support from Roche. JM: honoraria from Kyowa and Seattle Genetics; consultancy or advisory role for Pharmacyclics, Bayer, Kite, a Gilead Company, Pfizer, Janssen, Juno/Celgene, Bristol‐Myers Squibb, Kyowa, Alexion, Fosun Kite, Innovent, Seattle Genetics, and BeiGene; speakers’ bureau participation for Kite, a Gilead Company, Kyowa, Bayer, Pharmacyclics/Janssen, Seattle Genetics, Acrotech/Aurobindo, BeiGene, Verastem, AstraZeneca, Juno/Celgene/Bristol Myers Squibb, Genentech/Roche, and AbbVie; research funding from Bayer, Kite, a Gilead Company, Juno/Celgene/Bristol‐Myers Squibb, Merck, Portola, Incyte, Genentech, Pharmacyclics, Seattle Genetics, Janssen, and Millennium. SdG: honoraria from Gilead Sciences, AbbVie, and Janssen; consultancy or advisory role for Gilead Sciences, AbbVie, and Janssen. JMV: honoraria from Kite, a Gilead Company, AbbVie, Epizyme, Janssen, AstraZeneca, Verastem, Miltenyi, Loxo, Allogene, Wugen, Celgene, Roche, Genentech, and Karyopharm; consultancy or advisory role for AbbVie, Janssen, Kite, a Gilead Company, AstraZeneca, Verastem, Miltenyi, Loxo, Allogene, Wugen, Roche, Genentech, Karyopharm, and Morphosis; research funding from AstraZeneca, Bristol‐Myers Squibb, Incyte, Kite, a Gilead Company, Novartis, Seattle Genetics, Loxo, and Epizyme; travel support from Roche Pakistan. NLB: consultancy or advisory role for ADC Therapeutics, Roche/Genentech, and Seattle Genetics; research funding from ADC Therapeutics, Autolus, Bristol‐Myers Squibb, Celgene, Forty Seven, Genentech, Janssen, Kite, a Gilead Company, Merck, Millennium, Pharmacyclics, and Seattle Genetics. YL: consultancy or advisory role for Kite, a Gilead Company, Janssen, Novartis, Celgene, Bluebird Bio, Juno, Legend, Sorrento, Gamida Cell, and Vineti; research funding from Kite, a Gilead Company, Janssen, Celgene, Bluebird Bio, Merck, and Takeda. AD: consultancy or advisory role for Janssen and Kite, a Gilead Company. PAM: employment with Colorado Blood Cancer Institute Medical Group; consultancy or advisory role for, speakers' bureau participation for, and research funding from Kite, a Gilead Company. AHG: employment with Regional Cancer Care Associates/OMI; leadership role at and stock or other ownership in Cancer Outcome Tracking Analysis (COTA); consultancy or advisory role for AstraZeneca, Celgene, Gilead Sciences, Kite, a Gilead Company, and Xcenda; research funding from Acerta, AstraZeneca, Celgene, Constellation, Genentech‐Hoffmann La Roche, Infinity, and Infinity Verastem. MJK: honoraria from, consultancy or advisory role for, and travel support from Kite, a Gilead Company, Novartis, and Miltenyi; research funding from Roche, Takeda, and Celgene. CAJ: honoraria from Kite, a Gilead Company, Celgene, Novartis, Pfizer, Precision Biosciences, Nkarta, Lonza, and AbbVie; consultancy or advisory role for and travel support from Kite, a Gilead Company, Celgene, Novartis, Bristol‐Myers Squibb, Precision Biosciences, Nkarta, and Lonza; speakers' bureau participation for Axis and Clinical Care Options; research funding from Pfizer. UF: honoraria from Kite, a Gilead Company. MCM: consultancy or advisory role for Gilead Sciences, Janssen Cilag, and Servier; research funding and travel support from Celgene. CT: honoraria from Gilead Sciences, Novartis, Celgene, Roche, and Janssen; consultancy or advisory role for Celgene, Roche, Novartis, and Janssen; research funding from Roche; travel support from Novartis, Roche, Gilead Sciences, and Janssen. JMT: stock or other ownership in Genmab, Corvus, Marker Therapeutics, and Bluebird Bio; consultancy or advisory role for Kite, a Gilead Company, Celgene, Immune Design, and Celldex Therapeutics; research funding from Bristol‐Myers Squibb, Kite, a Gilead Company, Spectrum Pharmaceuticals, and Merck; travel support from Bristol‐Myers Squibb and Kite, a Gilead Company. PS: honoraria from and consultancy or advisory role for MorphoSys, Karyopharm, and Crispr; researching funding from Kite, a Gilead Company, Incyte, Amgen, Gamida Cell, Macrogenics, Cellectar, and Bristol‐Myers Squibb. IA: no relevant financial relationships to disclose. DT: consultancy or advisory role for Partner, Takeda, EUSA, Kite, a Gilead Company, Kyowa Kirin, and Magenta; speakers' bureau participation for Takeda and Kite, a Gilead Company; research funding from Bristol‐Myers Squibb, Kite, a Gilead Company, Genentech, Incyte, and Fate. JJK, JM, YZ, and LG: employment with Kite, a Gilead Company; stock or other ownership in Gilead Sciences. ZB: employment with Kite, a Gilead Company; stock or other ownership in OmniacPharmConsult Ltd. JMR: former employment with Kite, a Gilead Company. LJ: employment with Kite, a Gilead Company, and Trillium Therapeutics; stock or other ownership in and patents, royalties, or other intellectual property from Trillium Therapeutics. TvM: honoraria from Celgene; consultancy or advisory role for Kite, a Gilead Company."

"Funding information The study was supported by Kite, a Gilead Company."