Impact of Head-of-Bed Posture on Brain Oxygenation in Patients with Acute Brain Injury: A Prospective Cohort Study.

"Conflicts of interest All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements) or nonfinancial interest (such as personal or professional relationships, affiliations, knowledge, or beliefs) in the subject matter or materials discussed in this article."

"Source of support No funding was received for this research."

"This prospective cohort study was conducted between February 2012 and September 2015 in the ICUs of two French university hospitals in Saint-Etienne and Grenoble, which had 23 general ICU beds and 9 neurological ICU beds, respectively. The Institutional Review Board of Saint-Etienne (Chairperson Professor P. Rusch; Saint-Etienne University Hospital, Saint-Etienne, France) approved the study design on December 26, 2011 (ref. 2011-A01565-36). Written informed consent was obtained from patients’ relatives before inclusion, when possible, or from a legally authorized representative. Informed consent was obtained from all individual participants included in the study. The study was retrospectively registered on September 15, 2015, at ClinicalTrials.gov (identifier NCT02549313). Clinical trial registration: ClinicalTrials.gov: NCT02549313."