Sensitivity of cohesin-chromatin association to high-salt treatment corroborates non-topological mode of loop extrusion.

"availability of data and materials the datasets supporting the conclusions of this article are available from the gene expression omnibus database under the accession number gse166387 [ 62 ]. availability of data and materials the datasets supporting the conclusions of this article are available from the gene expression omnibus database under the accession number gse166387"

"Declarations Ethics approval and consent to participateNot applicable. Consent for publicationNot applicable. Competing interestsThe authors declare no competing interests. Competing interests The authors declare no competing interests."

"Funding This work was supported by the Russian Foundation for Basic Research (18-29-07001). Part of this work (the genome sequencing) was supported by grant 075-15-2019-1661 from the Ministry of Science and Higher Education of the Russian Federation."