Strategies for controlling the innate immune activity of conventional and self-amplifying mRNA therapeutics: Getting the message across.

"Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper."

"An-Katrien Minnaert and Helena Vanluchene are doctoral fellows from the Research Foundation-Flanders, Belgium (FWO Vlaanderen) with grant numbers 1S28420N (FWO-SB) and 11A6320N (FWO) respectively. Rein Verbeke is supported by a UGent BOF postdoc grant (BOF20/PDO/041). The authors would like to acknowledge funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No 810685 (DelNam project), the Research Foundation-Flanders, Belgium (FWO-Vlaanderen; grant No. G040319N and grant No. G016221N), the Research Foundation “Kom op Tegen Kanker” (grant No. FAF-C/2018/1213), Ghent University Concerted Research Action (grant No. BOF21/GOA/033) and the European Joint Programme on Rare Diseases (FWO-ERA-Net grant No. G0H7520N)."