Quantitative Biomarkers for Cancer Detection Using Contrast-Free Ultrasound High-Definition Microvessel Imaging: Fractal Dimension, Murray's Deviation, Bifurcation Angle & Spatial Vascularity Pattern.

"This work was supported in part by the grants from the National Institutes of Health and the National Cancer Institute under Grant R01 CA239548 and Grant R01 CA195527 and in part by the grant from the National Heart, Lung and Blood under Grant R01 HL148664. Study conception and design: Mostafa Fatemi and Azra Alizad, Methodology: Mostafa Fatemi and Azra Alizad, Software: Redouane Ternifi and Yinong Wang, Quantification Parameters’ Algorithms: Redouane Ternifi and Yinong Wang, Validation: Yinong Wang, Robert T. Fazzio, Mostafa Fatemi, and Azra Alizad, Formal analysis: Redouane Ternifi and Eric C. Polley, Investigation: Redouane Ternifi, Yinong Wang, Mostafa Fatemi, and Azra Alizad, Resources: Mostafa Fatemi, Azra Alizad, and Robert T. Fazzio, Data Curation: Redouane Ternifi and Yinong Wang, Writing-Original Draft: Redouane Ternifi, Yinong Wang, and Azra Alizad, Critical Revision: Mostafa Fatemi, Eric C. Polley, Robert T. Fazzio, and Azra Alizad, Visualization: RT, Yinong Wang, Robert T. Fazzio, Mostafa Fatemi, and Azra Alizad, Supervision: Mostafa Fatemi and Azra Alizad, Project Administration: Mostafa Fatemi and Azra Alizad, and Funding Acquisition: Mostafa Fatemi and Azra Alizad. All the authors read and approved the final manuscript."