Leptin brain entry via a tanycytic LepR-EGFR shuttle controls lipid metabolism and pancreas function.

"Competing Interets: The authors have no competing interests to declare."

"This work was supported by the Agence National de la Recherche (ANR-15-CE14-0025 to VP, RJ and SG and ANR-17-CE14-0034 to JSA), the European Research Council (ERC Synergy Grant WATCH No 810331 to VP, RN and MS), the National Institute of Health (NIH grant R01DK123002 to Y-BK and VP), « European Genomic Institute for Diabetes » (E.G.I.D, ANR-10-LABX-0046 to JSA and VP), DISTALZ (ANR-11-LABX-0009 to VP), I-SITE ULNE (ANR-16-IDEX-0004), the “Who am I?” (ANR-11-LABX-0071 to JD), the DHU Autoimmune and Hormonal Diseases (Authors) (JD), European Foundation for the Study of Diabetes (EFSD, to JSA), the Université de Lille (to MD, CB and JSA), Fondation pour la Recherche Médicale (FRM, to MD) and the H2020-MSCA-IF-2016 grant GLUCOTANYCYTES No 748134 to MI. We thank Laure Rolland for excellent technical help with immunofluorescence analysis of pancreatic sections and Raphaёl Boutry and the UMR 8199 LIGAN-PM Genomic platform (ANR-10-EQPX-07-01) belonging to EGID for Kinome assays. We thank the UMS2014-US41 for technical support."