Changes in Immune Cell Types with Age in Breast are Consistent with a Decline in Immune Surveillance and Increased Immunosuppression.

"data availability the publicly available gene expression data used in the present study can be accessed from the ncbi geo database under accession number gse102088 (24). data availability the publicly available gene expression data used in the present study can be accessed from the ncbi geo database under accession number gse102088"

"Declarations Ethics Approval and Consent to ParticipateThis study was approved by the Institutional Review Board (IRB) in accordance with the institutional guidelines at COH National Medical Center (IRB no. 17185 and 15418) after obtaining written informed consent. All donors whose biological material is included in this study signed an informed consent form prior to surgery or blood draw, allowing the use of their tissue and medical data for scientific research. Consent for PublicationAll donors signed an informed consent form prior to surgery, allowing use of their tissue and medical data for scientific research, including scientific publication. All donor information was de-identified before using in this study. Competing InterestsThe authors declare that they have no competing interests. Competing Interests The authors declare that they have no competing interests."

"Funding DOD CDMRP (BC141351 Era of Hope Scholar Award & BC181737), Hilton-Ludwig Foundation, and City of Hope Center for Cancer and Aging to MAL; National Institutes of Health/National Cancer Institute (NIH/NCI) grants R01CA237602, U01CA244109, R33AG059206, and R01EB024989 to MAL; R01CA170851, P20CA24619, R01CA192914, and U01CA189283 to VLS; NCI Cancer Metabolism Training Program Postdoctoral Fellowship T32CA221709 to RWS; and the NCI grant P30CA033572 supporting research carried out at the COH Core Facilities (Solid Tumor Pathology Core, Biomarker Analysis and Validation for Population Sciences Core, and Analytical Cytometry Core). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript."