Quantitative Systems Pharmacology Modeling of Avadomide-Induced Neutropenia Enables Virtual Clinical Dose and Schedule Finding Studies.

"we aimed at providing a detailed explanation of all the assumptions that went into the development of the model in order to make it easier for modelers and scientists in general not only to reproduce it using their favorite coding language ( ) (r code available in the supplementary materials ) but also to expand and leverage it for the development of models of neutropenia that are applied to other diseases ( ) and therapeutic contexts (e g beta-hemoglobinopathies ( )). we aimed at providing a detailed explanation of all the assumptions that went into the development of the model in order to make it easier for modelers and scientists in general not only to reproduce it using their favorite coding language ( ) (r code available in the supplementary materials ) but also to expand and leverage it for the development of models of neutropenia that are applied to other diseases ( ) and therapeutic contexts (e g beta-hemoglobinopathies ( ))."

"Declarations Conflict of InterestRAA, MP, SC, DWP, SK, MM, MWBT, RL, and AVR declare employment at Bristol Myers Squibb. MP, SC, DWP, SK, MM, MWBT, RL, CCS, AVR declare equity ownership in Bristol Myers Squibb. Conflict of Interest RAA, MP, SC, DWP, SK, MM, MWBT, RL, and AVR declare employment at Bristol Myers Squibb. MP, SC, DWP, SK, MM, MWBT, RL, CCS, AVR declare equity ownership in Bristol Myers Squibb."