Patent Foramen Ovale Closure Decreases the Incidence but Not the Size of New Brain Infarction on Magnetic Resonance Imaging: An Analysis of the REDUCE Trial.

"Disclosures Drs Messé, Andersen, Iversen, Roine, Sjöstrand, Rhodes, Søndergaard, and Kasner received grant funding from WL Gore and Associates. Dr Messé reports grants from Novartis, Biogen, and Mallinkrodt outside the submitted work. Dr Kasner reports grants and personal fees from Medtronic, personal fees from Abbott, grants and personal fees from Bristol-Myers Squibb, and personal fees from Abbvie outside the submitted work. The other authors report no conflicts."

"Sources of Funding The REDUCE PFO Closure Trial was sponsored by WL Gore & Associates, although there was no funding provided to the authors for this analysis. Dr Davatzikos has received funding from the National Institutes of Health related to the imaging analysis."

"Registration:: URL: https://www.clinicaltrials.gov; Unique identifier: NCT00738894."