The combined effect of lifestyle intervention and antioxidant therapy on sperm DNA fragmentation and seminal oxidative stress in IVF patients: a pilot study.

"CONFLICT OF INTEREST: None declared."

"The Central Denmark Region Committees on Health Research Ethics approved the conduct of this study, file number 1-10-72-148-19. The study was registered at clinicaltrials.gov: NCT03898752. All participants provided written informed consent. Conclusion:: A 3-month lifestyle intervention program combined with antioxidant therapy reduced DFI in infertile men with elevated SDF and a history of failed IVF/ICSI. A personalized lifestyle and antioxidant intervention could improve fertility of subfertile couples through a reduction in DFI, albeit controlled trials evaluating reproductive outcomes are needed before firm conclusions can be made.: Trial registration number and date: clinicaltrials.gov NCT03898752, April 2, 2019."