Integrin β1 orchestrates the abnormal cell-matrix attachment and invasive behaviour of E-cadherin dysfunctional cells.

"Declarations Conflict of InterestThe authors declare no competing of financial and non-financial interest. Conflict of Interest The authors declare no competing of financial and non-financial interest."

"Funding This work was financed by FEDER funds through the Operational Programme for Competitiveness Factors (COMPETE 2020), Programa Operacional de Competitividade e Internacionalização (POCI) and Programa Operacional Regional do Norte (Norte 2020); by National Funds through the Portuguese Foundation for Science and Technology (FCT projects PTDC/MED-GEN/30356/2017, PTDC/BTM-SAL/30383/2017, PTDC/BIM-ONC/0281/2014, NORTE-01-0145-FEDER-000029, and doctoral grant SFRH/BD/130708/2017-MG); and by the National Science Foundation (NSF grants CMMI-1362922 and CMMI-1910401). RMF and EMS are funded by the “FCT Scientific Employment Stimulus—Individual Call” program (CEECIND/01854/2017 and CEECIND/00622/2017). We acknowledge the American Association of Patients with Hereditary Gastric Cancer “No Stomach for Cancer” for funding Seruca’s and Figueiredo’s research."