Comparative Efficacy and Safety of Targeted Therapies for Chronic Thromboembolic Pulmonary Hypertension: A Systematic Review and Network Meta-Analysis.

"Conflicts of Interest The authors declare that they have no conflicts of interest."

"This work was supported by the National Natural Science Foundation of China under grant award number 81870233."

"This study, including its inclusion and exclusion criteria, literature sources and searches, data extraction, quality assessment and risk of bias assessment, and data synthesis and analysis, was conducted under the Cochrane criteria [] and the PRISMA guidelines [, ]. Items for the systematic review and NMA were identified based on an a priori protocol (PROSPERO: CRD42020173765) []. Methods: We searched PubMed, EMBASE, Web of Science, the Cochrane Central Register, https://clinicaltrials.gov, and who.int/trialsearch/, for relevant RCTs published up to January 2020. In addition to traditional meta-analysis, we also performed NMA in our systematic review, as deployed in a previous protocol (PROSPERO: CRD42020173765). "