Evaluation of the drug-drug interaction potential of treosulfan using a physiologically-based pharmacokinetic modelling approach.

"data availability statement pbpk models for midazolam digoxin and omeprazole are available on https://github com/open-systems-pharmacology/osp-pbpk-model-library ."

"the ddi scenarios were simulated using the developed pbpk model of treosulfan in combination with previously developed and published pbpk models of the substrates available as templates from the open systems pharmacology (osp) github model template repositories the recalculation of the ic 50 values to k i values resulted in k i values of 1213 ?; data availability statement pbpk models for midazolam digoxin and omeprazole are available on https://github com/open-systems-pharmacology/osp-pbpk-model-library ."

"COMPETING INTERESTS S.S., F.S.M. and P.B. are employees of esqLABS GmbH, the contract research organization (CRO) contracted by medac for this work. D.W.B. and R.A.H. report no conflict of interest. S.B., J.B. and C.H. are employees of medac GmbH, and A.R. was an employee of medac GmbH at the time of the investigation."

"Funding information medac GmbH"