Discovery and functional characterization of N-(thiazol-2-yl)-benzamide analogs as the first class of selective antagonists of the Zinc-Activated Channel (ZAC).

"Declaration of Competing Interest: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper."

"This study was supported financially by the Danish Council of Independent Research for Medical Sciences, the Carlsberg Foundation, NIH-National Institute of Mental Health (MH097446), and National Institute of Neurological Disorders and Stroke (NS108378, NS111064 and NS111338). M.Sc. Louise M. Rahr and M.Sc. Sarah B. Thygesen are thanked for excellent work in connection with the compound library screening. CRediT authorship contribution statement: Nawid Madjroh: Data curation, Formal analysis, Investigation, Visualization, Writing - review & editing. Eleni Mellou: Data curation, Formal analysis, Writing - review & editing. Paul A. Davies: Formal analysis, Investigation, Supervision, Writing - review & editing. Pella C. Söderhielm: Formal analysis, Investigation, Supervision, Writing - review & editing. Anders A. Jensen: Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Project administration, Supervision, Visualization, Writing - original draft, Writing - review & editing."