Efficacy of Prucalopride for Chronic Idiopathic Constipation: An Analysis of Participants With Moderate to Very Severe Abdominal Bloating.

"CONFLICTS OF INTEREST Guarantor of the article: Kyle Staller, MD, MPH. Specific author contributions: K.S.: contributed to the planning and conduct of the analysis, interpretation of the data and drafting of the manuscript, and has approved the final submitted draft. J.H.: contributed to the planning and conduct of the analysis, interpretation of the data and drafting of the manuscript, and has approved the final submitted draft. R.K.: contributed to the planning and conduct of the analysis, interpretation of the data and drafting of the manuscript, and has approved the final submitted draft. W.S.: contributed to the planning and conduct of the analysis, interpretation of the data and drafting of the manuscript, and has approved the final submitted draft. A.L.: contributed to the planning and conduct of the analysis, interpretation of the data and drafting of the manuscript, and has approved the final submitted draft. Financial support: The clinical trials included in this analysis were funded by Shire International GmbH, Johnson and Johnson and Movetis, and Shire-Movetis NV or Janssen Research and Development. This analysis was funded by Shire Human Genetic Therapies, Inc., a Takeda company. Potential competing interests: K. Staller has received consultancy fees from Arena, Boston Pharmaceuticals, Gelesis, and Synergy; has received speaker and consultancy fees from Shire, a Takeda company; and has received research fees from AstraZeneca, Gelesis, Ironwood, and Urovant. J. Hinson is an employee of Takeda Development Centre Americas, Inc., and a stockholder of Takeda Pharmaceutical Company Limited. R. Kerstens is an employee of Orion Statistical Consulting BV, which received funding from Shire Human Genetic Therapies, Inc., a Takeda company, for this analysis. William Spalding is an employee of Takeda Development Centre Americas, Inc, and a stockholder of Takeda Pharmaceutical Company Limited. Anthony Lembo has received research funding and consultancy fees from Shire, a Takeda company, and Takeda, Arena, Ardelyx, Ironwood, Vibrant, Mylan, Bayer, Gelesis, and Orphomed."

"Financial support : The clinical trials included in this analysis were funded by Shire International GmbH, Johnson and Johnson and Movetis, and Shire-Movetis NV or Janssen Research and Development. This analysis was funded by Shire Human Genetic Therapies, Inc., a Takeda company."