Serum Phosphate, BMI, and Body Composition of Middle-Aged and Older Adults: A Cross-Sectional Association Analysis and Bidirectional Mendelian Randomization Study.

"Notes: The generation and management of GWAS genotype data for the Rotterdam Study (RS I, RS II, RS III) was executed by the Human Genotyping Facility of the Genetic Laboratory of the Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands. The GWAS data sets are supported by the Netherlands Organisation of Scientific Research NWO Investments (No. 175.010.2005.011, 911-03-012), the Genetic Laboratory of the Department of Internal Medicine, Erasmus MC, the Research Institute for Diseases in the Elderly (014-93-015; RIDE2), and the Netherlands Genomics Initiative (NGI)/Netherlands Organisation for Scientific Research (NWO) Netherlands Consortium for Healthy Aging (NCHA), project No. 050-060-810.: The Rotterdam Study is funded by Erasmus Medical Center and Erasmus University; Netherlands Organization for the Health Research and Development (ZonMw); the Research Institute for Diseases in the Elderly (RIDE); the Ministry of Education, Culture, and Science; the Ministry for Health, Welfare, and Sports; the European Commission (DG XII); and the Municipality of Rotterdam. AB is supported by a grant from Health∼Holland (PhosphoNorm; LSHM18029). The funders played no role in the study design or in data collection and analysis.: Author disclosures: The authors report no conflicts of interest.: Supplemental Figures 1–4 and Supplemental Tables 1–13 are available from the “Supplementary data” link in the online posting of the article and from the same link in the online table of contents at https://academic.oup.com/jn/.: Data can be obtained upon request. Requests should be directed towards the management team of the Rotterdam Study (datamanagement.ergo@erasmusmc.nl), which has a protocol for approving data requests. Because of restrictions based on privacy regulations and informed consent of the participants, data cannot be made freely available in a public repository.: Abbreviations used: CKD, chronic kidney disease; CUE, continuously updating estimator; eGFR, estimated glomerular filtration rate; FGF23, fibroblast growth factor 23; GRS, genetic risk score; GWAS, genome-wide associated study; IV, instrumental variable; LMI, lean mass index; MR, Mendelian randomization; PTH, parathyroid hormone; RS, Rotterdam Study; SNP, single-nucleotide polymorphism; WHR, waist-to-hip ratio; 1,25(OH)2D, 1,25-dihydroxyvitamin D; 25(OH)D, 25-hydroxyvitamin D; 2sls, 2-stage least squares."

"Notes: The generation and management of GWAS genotype data for the Rotterdam Study (RS I, RS II, RS III) was executed by the Human Genotyping Facility of the Genetic Laboratory of the Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands. The GWAS data sets are supported by the Netherlands Organisation of Scientific Research NWO Investments (No. 175.010.2005.011, 911-03-012), the Genetic Laboratory of the Department of Internal Medicine, Erasmus MC, the Research Institute for Diseases in the Elderly (014-93-015; RIDE2), and the Netherlands Genomics Initiative (NGI)/Netherlands Organisation for Scientific Research (NWO) Netherlands Consortium for Healthy Aging (NCHA), project No. 050-060-810.: The Rotterdam Study is funded by Erasmus Medical Center and Erasmus University; Netherlands Organization for the Health Research and Development (ZonMw); the Research Institute for Diseases in the Elderly (RIDE); the Ministry of Education, Culture, and Science; the Ministry for Health, Welfare, and Sports; the European Commission (DG XII); and the Municipality of Rotterdam. AB is supported by a grant from Health∼Holland (PhosphoNorm; LSHM18029). The funders played no role in the study design or in data collection and analysis.: Author disclosures: The authors report no conflicts of interest.: Supplemental Figures 1–4 and Supplemental Tables 1–13 are available from the “Supplementary data” link in the online posting of the article and from the same link in the online table of contents at https://academic.oup.com/jn/.: Data can be obtained upon request. Requests should be directed towards the management team of the Rotterdam Study (datamanagement.ergo@erasmusmc.nl), which has a protocol for approving data requests. Because of restrictions based on privacy regulations and informed consent of the participants, data cannot be made freely available in a public repository.: Abbreviations used: CKD, chronic kidney disease; CUE, continuously updating estimator; eGFR, estimated glomerular filtration rate; FGF23, fibroblast growth factor 23; GRS, genetic risk score; GWAS, genome-wide associated study; IV, instrumental variable; LMI, lean mass index; MR, Mendelian randomization; PTH, parathyroid hormone; RS, Rotterdam Study; SNP, single-nucleotide polymorphism; WHR, waist-to-hip ratio; 1,25(OH)2D, 1,25-dihydroxyvitamin D; 25(OH)D, 25-hydroxyvitamin D; 2sls, 2-stage least squares."