Long-acting cabotegravir and rilpivirine for HIV-1 suppression: switch to 2-monthly dosing after 5 years of daily oral therapy.

"Conflicts of interest A.M. has received research funding and consulting fees from ViiV Healthcare, Gilead, Janssen Pharmaceuticals, and Merck, and consulting fees from Shionogi & Co., Ltd. G.J.R. reports grants from Gilead, ViiV Healthcare, and TaiMed. C.N. reports consulting fees from GlaxoSmithKline and ViiV Healthcare, and research support from GlaxoSmithKline and Gilead. O.O. received consulting fees from Gilead, ViiV Healthcare, and Merck. J.C. reports grants, consulting fees, and speaker fees from Gilead, ViiV Healthcare, and Merck. C.B. has received speaker fees from ViiV Healthcare and Gilead and other from GlaxoSmithKline, Janssen Pharmaceuticals, and Sangamo, outside the submitted work. J.D.V. has nothing to disclose. D.A.M. was an employee of ViiV Healthcare and stockholder of GlaxoSmithKline. K.C.S., C.M., C.G., and W.R.S. are employees of ViiV Healthcare and stockholders of Glaxo-SmithKline. V.W., S.H., and J.R. are employees and stockholders of GlaxoSmithKline. K.V. is an employee and stockholder of Janssen Pharmaceuticals. Previous presentation: IDWeek; October 21–25, 2020; Virtual; Oral."

"The POLAR study (NCT03639311) was funded by ViiV Healthcare and Janssen Pharmaceuticals."

"POLAR is a Phase 2b, open-label, multicenter (Canada and the USA), nonrandomized rollover study assessing the efficacy and safety of i.m. CAB+RPV long-acting Q2M in ART-experienced adults living with HIV-1 who received once-daily oral CAB+RPV treatment in the Phase 2b LATTE study (Fig. a). The full study protocol is available at ClinicalTrials.gov: NCT03639311. In brief, eligible participants were at least 18 years of age, virologically suppressed, and had completed at least 300 weeks of the LATTE study with plasma HIV-1 RNA less than 50 copies/ml at Week 300. If participants had plasma HIV-1 RNA greater than or equal to 50 copies/ml at Week 300, a single repeat test to determine eligibility was allowed after consultation with the medical monitor. Participants from LATTE were excluded if they had two or more sequential plasma HIV-1 RNA greater than or equal to 50 copies/ml or any plasma HIV-1 RNA greater than or equal to 200 copies/ml in the last 6 months."