Mechanism of activation and the rewired network: New drug design concepts.

"CONFLICT OF INTERESTS The authors declare that there are no conflict of interests."

"The results shown here are in whole or part based upon data generated by TCGA Research Network (https://www.cancer.gov/tcga). The authors would like to acknowledge the American Association for Cancer Research and its financial and material support in the development of the AACR Project GENIE registry, as well as members of the consortium for their commitment to data sharing. Interpretations are the responsibility of the study authors. The cell line data underlying the results presented in the study are available from GDSC (https://www.cancerrxgene.org/downloads), Cell Model Passports (https://cellmodelpassports.sanger.ac.uk/downloads), and The Cancer Dependency Map project (https://depmap.org/portal/download). The PDX data underlying the results presented in the study are available in Gao et al. This project has been funded in whole or in part with federal funds from the National Cancer Institute, National Institutes of Health, under contract HHSN261201500003I. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products or organizations imply endorsement by the US Government. This study was supported [in part] by the Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research, and the Intramural Research Program of the NIH Clinical Center."