Long-term efficacy of first-line ibrutinib treatment for chronic lymphocytic leukaemia in patients with TP53 aberrations: a pooled analysis from four clinical trials.

"Conflicts of interest JNA: honoraria from AstraZeneca, Janssen, and AbbVie; consulting/advisory role for AstraZeneca, Pharmacyclics LLC, an AbbVie Company, BeiGene, AbbVie, Genentech, TG Therapeutics, Ascentage, ADC Therapeutics and Epizyme; research funding from Celgene, Genentech, AstraZeneca, TG Therapeutics and Janssen; and speakers bureau for AbbVie, Janssen, Pharmacyclics LLC, an AbbVie Company, AstraZeneca and BeiGene. TS: honoraria from Vanderbilt University, Cornell University, Eastside Health Network, Emory University, University of Nebraska, Columbia University, Memorial Sloan Kettering, Coalition for Physician Well‐Being, Washington Hospital, Nevada Physician Wellness Coalition, St. Christopher’s Hospital for Children, American Society for Nephrology, Lankenau Medical Center, Physicians’ Education Resource, Adventist Health Care, Advocate Health Care, Vancouver Physician Staff Association, Advent Health Care and Hospital for Special Surgery; research funding from Genentech, Pharmacyclics LLC, an AbbVie Company and AbbVie; and patents/royalties/other intellectual property with Mayo Clinic. AW: research funding from Pharmacyclics LLC, an AbbVie Company, Acerta, Merck, Nurix, Verastem and Genmab; and patents/royalties/other intellectual property with National Institutes of Health. CM: consulting/advisory role for Janssen, AbbVie, BioGene and AstraZeneca; research funding from AbbVie and Janssen; and speakers bureau for AbbVie and Janssen. SMO: consulting or advisory role for Amgen, Astellas, Celgene, GlaxoSmithKline, Janssen, Aptose Biosciences, Vaniam Group, AbbVie, Alexion, Verastem, Eisai, Juno Therapeutics, Vida Ventures, Autolus, Johnson & Johnson, Merck, Bristol Myers Squibb, Gilead, Pharmacyclics LLC, an AbbVie Company, TG Therapeutics, Pfizer, NOVA Research Company and Sunesis; and research funding from Kite, Regeneron, Acerta, Gilead, Pharmacyclics LLC, an AbbVie Company, TG Therapeutics, Pfizer, Caribou and Sunesis. JL: employment with AbbVie and Summit Therapeutics; and stock or other ownership with AbbVie, Summit Therapeutics, Gilead, Vertex Pharmaceuticals, ALX Oncology, I‐Mab Biopharma, Surface Oncology, Moderna, Trillium Therapeutics, Pfizer, Novavax, BioMarin, Oncternal Therapeutics, Iovance Biotherapeutics, Fate Therapeutics, BeiGene, TG Therapeutics and Arbutus Biopharma. GK: employment with Pharmacyclics LLC, an AbbVie Company, AbbVie and Bristol Myers Squibb; stock or other ownership with AbbVie, Bristol Myers Squibb, Moderna, Dynavax and Inovio; and travel/accommodations/expenses from Bristol Myers Squibb. JPD: employment with Pharmacyclics LLC, an AbbVie Company; and stock or other ownership with AbbVie. IEA: nothing to disclose."

"Funding information This study was supported by Pharmacyclics LLC, an AbbVie Company."