Enhancing Discovery of Genetic Variants for Posttraumatic Stress Disorder Through Integration of Quantitative Phenotypes and Trauma Exposure Information.

"deposited data; public database million veteran program summary data pmid: 33510476 na dbgap study accession phs001672 v4 p1 deposited data; public database pgc-ptsd genotype and phenotype data pmid: 31594949 na https://www med unc edu/pgc/shared-methods/data-access-portal/ deposited data; public database uk biobank pmid: 30305743 na https://www ukbiobank ac uk/ software; algorithm fuma version 1 3 6a pmid:29184056 rrid:scr_017521 https://fuma ctglab nl/ software; algorithm metal pmid: 20616382 rrid:scr_002013 http://csg sph umich edu//abecasis/metal/ software; algorithm bolt lmm pmid: 25642633 na https://www hsph harvard edu/po-ru-loh/software/ software; algorithm ricopili genetic pipeline pmid: 31393554 rrid:scr_004496 http://www broadinstitute org/mpg/ricopili/ software; algorithm ld score regression pmid: 25642630 na https://github com/bulik/ldsc software; algorithm ld hub pmid: 27663502 na http://ldsc broadinstitute org software; algorithm gwas atlas pmid: 31566222 na https://atlas ctglab nl/ software; algorithm fastqtl pmid: 26708335 rrid:scr_016093 http://fastqtl sourceforge net/ software; algorithm mtag pmid: 29292387 na https://github com/jonjala/mtag deposited data; public database million veteran program summary data pmid: 33510476 na dbgap study accession phs001672 v4 p1 deposited data; public database pgc-ptsd genotype and phenotype data pmid: 31594949 na https://www med unc edu/pgc/shared-methods/data-access-portal/ deposited data; public database uk biobank pmid: 30305743 na https://www ukbiobank ac uk/ software; algorithm fuma version 1 3 6a pmid:29184056 rrid:scr_017521 https://fuma ctglab nl/ software; algorithm metal pmid: 20616382 rrid:scr_002013 http://csg sph umich edu//abecasis/metal/ software; algorithm bolt lmm pmid: 25642633 na https://www hsph harvard edu/po-ru-loh/software/ software; algorithm ricopili genetic pipeline pmid: 31393554 rrid:scr_004496 http://www broadinstitute org/mpg/ricopili/ software; algorithm ld score regression pmid: 25642630 na https://github com/bulik/ldsc software; algorithm ld hub pmid: 27663502 na http://ldsc broadinstitute org software; algorithm gwas atlas pmid: 31566222 na https://atlas ctglab nl/ software; algorithm fastqtl pmid: 26708335 rrid:scr_016093 http://fastqtl sourceforge net/ software; algorithm mtag pmid: 29292387 na https://github com/jonjala/mtag deposited data; public database uk biobank pmid: 30305743 na https://www ukbiobank ac uk/ software; algorithm fuma version 1 3 6a pmid:29184056 rrid:scr_017521"

"deposited data; public database million veteran program summary data pmid: 33510476 na dbgap study accession phs001672 v4 p1 deposited data; public database pgc-ptsd genotype and phenotype data pmid: 31594949 na https://www med unc edu/pgc/shared-methods/data-access-portal/ deposited data; public database uk biobank pmid: 30305743 na https://www ukbiobank ac uk/ software; algorithm fuma version 1 3 6a pmid:29184056 rrid:scr_017521 https://fuma ctglab nl/ software; algorithm metal pmid: 20616382 rrid:scr_002013 http://csg sph umich edu//abecasis/metal/ software; algorithm bolt lmm pmid: 25642633 na https://www hsph harvard edu/po-ru-loh/software/ software; algorithm ricopili genetic pipeline pmid: 31393554 rrid:scr_004496 http://www broadinstitute org/mpg/ricopili/ software; algorithm ld score regression pmid: 25642630 na https://github com/bulik/ldsc software; algorithm ld hub pmid: 27663502 na http://ldsc broadinstitute org software; algorithm gwas atlas pmid: 31566222 na https://atlas ctglab nl/ software; algorithm fastqtl pmid: 26708335 rrid:scr_016093 http://fastqtl sourceforge net/ software; algorithm mtag pmid: 29292387 na https://github com/jonjala/mtag"

"ACKNOWLEDGMENTS AND DISCLOSURES This work was supported by the National Institute of Mental Health/ U.S. Army Medical Research and Development Command (Grant No. R01MH106595 [to CMN, IL, MBS, KJRe, and KCK], National Institutes of Health (Grant No. 5U01MH109539 to the Psychiatric Genomics Consortium), and Brain & Behavior Research Foundation (Young Investigator Grant [to KWC]). Genotyping of samples was provided in part through the Stanley Center for Psychiatric Genetics at the Broad Institute supported by Cohen Veterans Bioscience. Statistical analyses were carried out on the LISA/Genetic Cluster Computer (https://userinfo.surfsara.nl/systems/lisa) hosted by SURFsara. This research has been conducted using the UK Biobank resource (Application No. 41209). This work would have not been possible without the financial support provided by Cohen Veterans Bioscience, the Stanley Center for Psychiatric Genetics at the Broad Institute, and One Mind. This material has been reviewed by the Walter Reed Army Institute of Research. There is no objection to its presentation and/or publication. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting true views of the U.S. Department of the Army or the Department of Defense. We thank the investigators who comprise the PGC-PTSD working group and especially the more than 206,000 research participants worldwide who shared their life experiences and biological samples with PGC-PTSD investigators. We thank Mark Zervas for his critical input. Full acknowledgments are in Supplement 1. MBS has in the past 3 years received consulting income from Actelion, Acadia Pharmaceuticals, Aptinyx, Bionomics, BioXcel Therapeutics, Clexio, EmpowerPharm, GW Pharmaceuticals, Janssen, Jazz Pharmaceuticals, and Roche/Genentech and has stock options in Oxeia Biopharmaceuticals and Epivario. In the past 3 years, NPD has held a part-time paid position at Cohen Veterans Bioscience, has been a consultant for Sunovion Pharmaceuticals, and is on the scientific advisory board for Sentio Solutions for unrelated work. In the past 3 years, KJRe has been a consultant for Datastat, Inc., RallyPoint Networks, Inc., Sage Pharmaceuticals, and Takeda. JLM-K has received funding and a speaking fee from COMPASS Pathways. MU has been a consultant for System Analytic. HRK is a member of the Dicerna scientific advisory board and a member of the American Society of Clinical Psycho-pharmacology Alcohol Clinical Trials Initiative, which during the past 3 years was supported by Alkermes, Amygdala Neurosciences, Arbor Pharmaceuticals, Dicerna, Ethypharm, Indivior, Lundbeck, Mitsubishi, and Otsuka. HRK and JG are named as inventors on Patent Cooperative Treaty patent application number 15/878,640, entitled “Genotype-guided dosing of opioid agonists,” filed January 24, 2018. RP and JG are paid for their editorial work on the journal Complex Psychiatry. OAA is a consultant to HealthLytix. All other authors report no biomedical financial interests or potential conflicts of interest."

"This work was supported by the National Institute of Mental Health/ U.S. Army Medical Research and Development Command (Grant No. R01MH106595 [to CMN, IL, MBS, KJRe, and KCK], National Institutes of Health (Grant No. 5U01MH109539 to the Psychiatric Genomics Consortium), and Brain & Behavior Research Foundation (Young Investigator Grant [to KWC]). Genotyping of samples was provided in part through the Stanley Center for Psychiatric Genetics at the Broad Institute supported by Cohen Veterans Bioscience. Statistical analyses were carried out on the LISA/Genetic Cluster Computer (https://userinfo.surfsara.nl/systems/lisa) hosted by SURFsara. This research has been conducted using the UK Biobank resource (Application No. 41209). This work would have not been possible without the financial support provided by Cohen Veterans Bioscience, the Stanley Center for Psychiatric Genetics at the Broad Institute, and One Mind."