Flow cytometric minimal residual disease assessment in B-cell precursor acute lymphoblastic leukaemia patients treated with CD19-targeted therapies - a EuroFlow study.

"Conflict of interest JJMvD, AO, JFM, TS and VHJvdV each report being one of the inventors on the EuroFlow‐owned patent PCT/NL2010/050332 (Methods, reagents and kits for flow cytometric immunophenotyping of normal, reactive and malignant leukocytes). The Infinicyt software is based on intellectual property of some EuroFlow laboratories (University of Salamanca in Spain and Federal University of Rio de Janeiro in Brazil) and the scientific input of other EuroFlow members. All above‐mentioned intellectual property and related patents are licensed to Cytognos (Salamanca, Spain) and BD Biosciences (San José, CA, USA), which companies pay royalties to the EuroFlow Consortium. These royalties are exclusively used for continuation of the EuroFlow collaboration and sustainability of the EuroFlow consortium. VHJvdV reports a Laboratory Services Agreement with BD Biosciences; all related fees are for the Erasmus MC. JJMvD and JAOMCV report an Educational Services Agreement from BD Biosciences and a Scientific Advisor Agreement with Cytognos; all related fees and honoraria are for the involved university departments at Leiden University Medical Centre and University of Salamanca. MB received personal fees from Incyte (advisory board) and Roche Pharma AG, financial support for reference diagnostics from Affimed, Amgen, BMS and Regeneron, grants and personal fees from Amgen (advisory board, speakers bureau, travel support), and personal fees from Janssen (speakers bureau), all outside the submitted work. The other authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest."

"Grant support and royalty income The EuroFlow Consortium received support from the FP6‐2004‐LIFESCIHEALTH‐5 programme of the European Commission (grant LSHB‐CT‐2006‐018708) as Specific Targeted Research Project (STREP). The EuroFlow Consortium is part of the European Scientific Foundation for Hemato‐Oncology (ESLHO), a Scientific Working Group (SWG) of the European Hematology Association (EHA). TS and LS were supported by a Scientific Grant from the Medical University of Silesia Nr. PCN‐1‐050/K/0/K."