Distinct sequence features underlie microdeletions and gross deletions in the human genome.

"data availability statement a pipeline is available at https://github com/qimengling/deletion_score_pipe for anyone with novel deletions."

"data availability statement a pipeline is available at https://github com/qimengling/deletion_score_pipe for anyone with novel deletions."

"CONFLICT OF INTERESTS The authors declare that there are no conflict of interests."

"This study was supported in part through computational resources provided by Bioinformatics and Omics Center, Sun Yat‐Sen Memorial Hospital, Sun Yat‐Sen University, and through HPC resources from the Texas Advanced Computing Center (TACC) at The University of Texas at Austin (URL: http://www.tacc.utexas.edu). This study was funded by grants from the National Key R&D Program of China (2020YFB0204803), the Natural Science Foundation of China (81801132, 81971190, 61772566), Guangdong Key Field R&D Plan (2019B020228001 and 2018B010109006), Introducing Innovative and Entrepreneurial Teams (2016ZT06D211), Guangzhou S&T Research Plan (202007030010) to H.Z. and by National Institutes of Health (NIH) grants (P01 CA092584 and R35 CA220430) to J.A.T. P.D.S., E.V.B and D.N.C. acknowledge the financial support of Qiagen Inc through a License Agreement with Cardiff University."