TNF receptor-related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF-κB-inducing kinase-mediated hepatocyte transdifferentiation.

"data deposition the rna-sequencing and single-cell rna-sequencing data reported in this study have been deposited in the gene expression omnibus database under the following accession numbers: gse178418 gse184276 (rna-sequencing data) and gse178814 (single-cell rna-sequencing data). data deposition the rna-sequencing and single-cell rna-sequencing data reported in this study have been deposited in the gene expression omnibus database under the following accession numbers: gse178418"

"CONFLICT OF INTEREST Nothing to report."

"Conceptualization : Yuto Shiode, Takahiro Kodama, and Tetsuo Takehara. Methodology : Yuto Shiode, Takahiro Kodama, Justin Y. Newberg, Jumpei Kondo, Nancy A. Jenkins, Neal G. Copeland, and Tetsuo Takehara. Experimentation : Yuto Shiode, Satoshi Shigeno, Kazuhiro Murai, and Satoshi Tanaka. Writing : Yuto Shiode and Takahiro Kodama. Funding acquisition : Takahiro Kodama, Tomohide Tatsumi, and Tetsuo Takehara. Resources : Yuto Shiode, Justin Y. Newberg, Jumpei Kondo, Shogo Kobayashi, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hiroshi Suemizu, and Hidetoshi Eguchi. Supervision : Tetsuo Takehara. Funding information Supported by the Japan Agency for Medical Research and Development (P21fk0310108h0005, to T.Tak.; JP21fk0210074, to T.K.; JP21fk021055h, to T.K.; and JP21fk0210091s, to T.K.) and by a Grant-in- Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology, Japan (20H03661, to T.K.)"