Exposure to environmentally relevant concentrations of ambient fine particulate matter (PM_2.5) depletes the ovarian follicle reserve and causes sex-dependent cardiovascular changes in apolipoprotein E null mice.

"Declarations Ethics approval and consent to participateAll experiments involving animals were approved by the University of California Irvine Institutional Animal Care and Use Committee and were performed in accordance with the Guide for the Care and Use of Laboratory Animals [101]. Consent for publicationNot applicable. Competing interestsThe authors declare that they have no competing interests. Competing interests The authors declare that they have no competing interests."

"Funding Funding was provided by California Air Resources Board Contract Number 16RD005 to M.T.K. and U.L.; NIH R01ES020454 to U.L.; and UC Irvine Summer Undergraduate Research Program Fellowships to J.D.N. and J.H.S. The authors are also grateful for funding from the U.S. Army Research Office DURIP Equipment Program (grant #W911NF2010064) for the LC–MS/MS system. The statements and conclusions in this report are those of the investigators and not necessarily those of the California Air Resources Board, the NIH or UC Irvine. The mention of commercial products, their source, or their use in connection with material reported herein is not to be construed as actual or implied endorsement of such products."