Randomised clinical trial: a phase 1b study of GB004, an oral HIF-1α stabiliser, for treatment of ulcerative colitis.

"Declaration of personal interests : Silvio Danese reports having served as a speaker, consultant, and advisory board member for Schering‐Plough, AbbVie, Actelion, Alphawasserman, AstraZeneca, Cellerix, Cosmo Pharmaceuticals, Ferring, Genentech, Grunenthal, Johnson and Johnson, Millenium Takeda, MSD, Nikkiso Europe GmbH, Novo Nordisk, Nycomed, Pfizer, Pharmacosmos, UCB Pharma and Vifor. Brian G. Feagan reports research/grant support: AbbVie Inc, Amgen Inc, AstraZeneca/MedImmune Ltd., Atlantic Pharmaceuticals Ltd., Boehringer‐Ingelheim, Celgene Corporation, Celltech, Genentech Inc/Hoffmann‐La Roche Ltd., Gilead Sciences Inc, GlaxoSmithKline (GSK), Janssen Research & Development LLC., Pfizer Inc, Receptos Inc / Celgene International, Sanofi, Santarus Inc, Takeda Development Center Americas Inc, Tillotts Pharma AG, UCB. Consultant: Abbott/AbbVie, AgomAB Therapeutics, Allakos, Allergan, Amgen, Applied Molecular Transport Inc, Aptevo Therapeutics, Astra Zeneca, Atlantic Pharma, BioMx Israel, Boehringer‐Ingelheim, Bristol‐Myers Squibb, Calypso Biotech, Celgene, Connect BioPharma, Disc Medicine Inc, Everest Clinical Research Corp., Galapagos, Galen Atlantica, Genentech/Roche, Gilead, Gossamer Pharma, GSK, Hoffmann‐LaRoche, Index Pharma, Janssen, Kyowa Kakko Kirin Co Ltd., Leadiant, Lilly, Lument AB, Merck, Millenium, Mylan, Nestles, Nextbiotix, Origo BioPharma, Pandion Therapeutics, ParImmune, Parvus Therapeutics Inc, Pfizer, Prometheus Therapeutics and Diagnostics, Progenity, Protagonist, Qu Biologics, Rebiotix, Receptos, Salix Pharma, Sandoz, Sanofi, Shire, Surrozen Inc, Takeda, Tillotts, UCB Pharma, VHsquared Ltd., Viatris, Ysios, Zealand Pharma. Speakers Bureau: AbbVie, Janssen, Takeda, Tillotts. Scientific advisory board: AbbVie, Allergan, Amgen, Astra Zeneca, Boehringer‐Ingelheim, Bristol‐MyersSquibb, Celgene, Genentech/Roche, Janssen, Novartis, Origo BioPharma, Pfizer, Prometheus, Protagonist, Takeda, Tillotts Pharma. Board of Directors: Senior Scientific Director – Alimentiv Inc, London. Shareholder: Gossamer Bio, Inc Rish K. Pai reports consulting fees from Alimentiv, Eli Lilly, Allergan, AbbVie, Verily and PathAI. William J. Sandborn reports research grants from Abbvie, Abivax, Arena Pharmaceuticals, Boehringer Ingelheim, Celgene, Genentech, Gilead Sciences, Glaxo Smith Kline, Janssen, Lilly, Pfizer, Prometheus Biosciences, Seres Therapeutics, Shire, Takeda, Theravance Biopharma; consulting fees from Abbvie, Abivax, Admirx, Alfasigma, Alimentiv (previously Robarts Clinical Trials, owned by Alimentiv Health Trust), Alivio Therapeutics, Allakos, Amgen, Applied Molecular Transport, Arena Pharmaceuticals, Bausch Health (Salix), Beigene, Bellatrix Pharmaceuticals, Boehringer Ingelheim, Boston Pharmaceuticals, Bristol Meyers Squibb, Celgene, Celltrion, Cellularity, Cosmo Pharmaceuticals, Escalier Biosciences, Equillium, Forbion, Genentech/Roche, Gilead Sciences, Glenmark Pharmaceuticals, Gossamer Bio, Immunic (Vital Therapies), Index Pharmaceuticals, Intact Therapeutics, Janssen, Kyverna Therapeutics, Landos Biopharma, Lilly, Oppilan Pharma (acquired by Ventyx Biosciences), Otsuka, Pandion Therapeutics, Pfizer, Progenity, Prometheus Biosciences, Prometheus Laboratories, Protagonists Therapeutics, Provention Bio, Reistone Biopharma, Seres Therapeutics, Shanghai Pharma Biotherapeutics, Shire, Shoreline Biosciences, Sublimity Therapeutics, Surrozen, Takeda, Theravance Biopharma, Thetis Pharmaceuticals, Tillotts Pharma, UCB, Vendata Biosciences, Ventyx Biosciences, Vimalan Biosciences, Vivelix Pharmaceuticals, Vivreon Biosciences, Zealand Pharma; stock or stock options from Allakos, BeiGene, Gossamer Bio, Oppilan Pharma (acquired by Ventyx Biosciences), Prometheus Biosciences, Prometheus Laboratories Progenity, Shoreline Biosciences, Ventyx Biosciences, Vimalan Biosciences, Vivreon Biosciences; and employee at Shoreline Biosciences. Spouse: Iveric Bio ‐ consultant, stock options; Progenity ‐ stock; Oppilan Pharma (acquired by Ventyx Biosciences) ‐ consultant, stock options; Prometheus Biosciences ‐ employee, stock, stock options; Prometheus Laboratories – stock, stock options, consultant; Ventyx Biosciences – stock, stock options; Vimalan Biosciences – stock, stock options. Barrett G. Levesque, Kristen Taylor Meadows, Brian J. Kirby, Jean‐Marie Bruey, Allan Olson, Robin Osterhout, Courtney Van Biene, Julia Ford, Richard Aranda, and Kartik Raghupathi are employees of Gossamer Bio, Inc Alina Jucov and BR Bhandari have nothing to disclose."

"Funding information"