APOE4 confers transcriptomic and functional alterations to primary mouse microglia.

"the rna-seq data generated in this publication have been deposited in ncbi's gene expression omnibus ( edgar et al 2002 ) and are accessible through geo series access number gse171280. interestingly genes significantly differentially expressed in e4 vs e3 microglia at a nominal p-value < 0 05 significantly overlapped with those identified as representative of an interferon-enriched subcluster of microglia in vivo [hypergeometric test p = 0 02 data from supplementary data 5 from ( )]."

"Declaration of Competing Interest: AMG has consulted for Eisai, Biogen, Pfizer, AbbVie, Cognition Therapeutics and GSK; she also serves on the Scientific Advisory Board of Genentech. JMC is a co-inventor listed on issued patents licensed by Alkahest, Inc. SIM, SMN, BMH, RK, MH, JDZ, DC, JMC, EM report no conflicts of interest."

"The authors would like to thank Dr. Anna Podlesny-Drabiniok, Dr. Francesca Garretti, Dr. Julia TCW for critical reading during the manuscript preparation as well as Dr. John Crary and Dr. Nikos Robakis for contributing to data discussion. All data generated or analyzed during this study will be made available upon request. The RNA-Seq data generated in this publication have been deposited in NCBI’s Gene Expression Omnibus (Edgar et al., 2002) and are accessible through GEO Series access number GSE171280. This study was funded by the JPB Foundation (AMG), BrightFocus Foundation (EM) and (JMC), NIA/NIH AG061382 (JMC) and NIA/NIH K99/R00 AG051711 (JMC). These funding organizations had no direct involvement in the study design, collection, analysis, or interpretation of results."