Locus coeruleus integrity is related to tau burden and memory loss in autosomal-dominant Alzheimer's disease.

"the here described lc meta mask as well as pontine reference mask is available for download on an open science framework repository ( osf io/sf2ky/ ).; pruning low-agreement voxels yielded a high-confidence lc volume of interest ( lc metamask; available for download via: osf io/sf2ky/ ) that matches the dimensions reported in post-mortem investigations ( ) and allows assessment of the accuracy of previously published masks3 1 2.; we hope that by sharing an unbiased biologically-plausible lc volume of interest that is based on more than 1000 participants and all commonly used sequence types (fse mt flash; see table 1 ) we assist future functional and structural imaging studies in classifying brainstem effects (this lc meta mask is available for download via osf io/sf2ky/ ).; sl # slice number in mni 152 lin (0 5 mm) space; the lc meta mask is available for download via: osf io/sf2ky/ ).; table 1: locus coeruleus masks included in comparisons publication mri acquisition sample locus coeruleus segmentaion mask source mask version betts et al 2017 3 t; flash n = 82; ya; oa manual https://doi org/10 1016/j neuroimage 2017 09 042 -- dahl et al 2019 3 t; tse n = 294; ya; oa semi-automatic https://www mpib-berlin mpg de/lc-map -- keren et al 2009 3 t; tse n = 44; ya-oa semi-automatic http://www eckertlab org/lc 1 sd liu et al 2019 3 t; mt n = 605; ya-oa manual https://osf io/r2bwk -- tona et al 2017 3 t; tse n = 17; ya manual http://www nitrc org/projects/prob_lc_3t 1 ye et al 2021 7 t; mt n = 53; oa semi-automatic https://www nitrc org/projects/lc_7t_prob 5% prob 2 note: 1 the masks provided by tona and colleagues were averaged across scan sessions and segmentations2 the mask by ye and colleagues was linearly and non-linearly co-registered from mni-icbm 152 non-linear 2009b to mni-icbm 152 linear space (0 5 mm resolution) using advanced normalization tools (antsregistration)."

"6.: Competing interests: The authors declare no competing financial interests."

"7. Funding MJD is recipient of a stipend from the GA. Lienert-Foundation and was supported by a stipend from the Davis School of Gerontology, University of Southern California. MM’s work was supported by National Institutes of Health (NIH) grant R01AG025340, an Alexander von Humboldt fellowship, and a Max Planck Sabbatical Award. MW-B received support from the German Research Foundation (DFG, WE 4269/5-1) and the Jacobs Foundation (Early Career Research Fellowship 2017–2019). BLK was supported by a NIH grant F32AG057162. YS was supported by NIH grants RF1AG064584 and RF1AG056573. SG, KH, and CCM were supported by P30AG066530, JMR was supported by NIH grants U01AG051218, R01AG062007, and P30AG066530. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. We thank Dr. Abhay Sagare for help with genotyping."