GLP1R Attenuates Sympathetic Response to High Glucose via Carotid Body Inhibition.

"rna-seq raw sequence files and summarized read counts are publicly available at gene expression omnibus under accession number: gse178504 to elucidate global gene expression changes driving the sensitized state we sequenced the polyadenylated transcriptomes of bilateral cb samples from age-matched (13 weeks old) male normotensive wistar-kyoto (wky/nhsd) and spontaneously hypertensive rat (nhsd) rats (figure 1 a). a full list of identified degs is provided in data set s1 .; j broichhagen and d j hodson have a licensing deal with celtarys research for production and supply of luxendins and other fluorophore-conjugated peptidic pharmacophores detailed materials and methods figures s1-s11 tables s1-s10 data sets1 and 2 references - nonstandard abbreviations and acronyms glp1 glucagon-like peptide-1 glp1r glucagon-like peptide-1 receptor gpcr g-protein-coupled receptor lfc log2 fold-change t2d type 2 diabetes tsna thoracic sympathetic nerve activity whbp working heart-brain preparation wky wistar kyoto rat * j f r panto and d murphy are joint last authors."

"Disclosures J. Broichhagen and D.J. Hodson have a licensing deal with Celtarys Research for production and supply of LUXendins and other fluorophore-conjugated peptidic pharmacophores"

"Sources of Funding British Heart Foundation (FS/17/60/33474); Health Research Council of New Zealand (19/687); BBSRC (BB/R016879/1); The Leverhulme Trust (RPG-2017-287); D.J. Hodson was supported by MRC (MR/N00275X/1 and MR/S025618/1) Project and Diabetes UK (17/0005681) Project Grants. This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (Starting Grant 715884 to D.J. Hodson)."