Exercise training worsens cardiac performance in males but does not change ejection fraction and improves hypertrophy in females in a mouse model of metabolic syndrome.

"Declarations Ethics approval and consent to participateThis investigation conformed to the EU Directive 2010/63/EU and was approved by the regional Animal Research Ethics Committee of Csongrád County (Csongrád county, Hungary; project license: XVI/766/2018). All institutional and national guidelines for the care and use of laboratory animals were followed. Consent for publicationNot applicable. Competing interestsThe authors declare that they have no competing interests. Competing interests The authors declare that they have no competing interests."

"Funding This research and publication were funded by the projects GINOP-2.3.2-15-2016-00040, GINOP-2.3.2-15-2016-00060, NKFIH K115990, NKFIH FK129094, NKFIH FK138390, TKP2021-EGA-32 and 20391-3/2018/FEKUSTRAT. MS (Márta Sárközy) is supported by the New National Excellence Program of the Ministry of Human Capacities (ÚNKP-20-5-SZTE-166, ÚNKP-19-4-SZTE-89) and the János Bolyai Research Fellowship of the Hungarian Academy of Sciences. BD is supported by the UNKP-21-4-SZTE-483 New National Excellence Program of the Ministry for Innovation and Technology."