Effect of Propionic Acid on Diabetes-Induced Impairment of Unfolded Protein Response Signaling and Astrocyte/Microglia Crosstalk in Rat Ventromedial Nucleus of the Hypothalamus.

"Conflicts of Interest The authors declare that there is no conflict of interest regarding the publication of this paper."

"This work was supported by a research grant of the Ministry of Health of Ukraine "Structural and functional changes of neurons of the mediobasal hypothalamus under condition of impaired carbohydrate and lipid metabolism" (state registration number 0119U101229). The authors would like to express their deepest gratitude to Prof. Ludmila Stechenko and Oksana Cryvosheyeva (Department of Histology and Embryology, Bogomolets National Medical University, Kyiv, Ukraine) for their help in performing electron microscopy and describing these data, Prof. Alexandr Grabovoy (Department of Histology and Embryology, Bogomolets National Medical University, Kyiv, Ukraine) for his involvement and valuable advices on immunohistochemical staining of the brain slices, and Dr. Artem Tykhomyrov, Dr. Sci. (Department of Enzyme Chemistry and Biochemistry, Palladin Institute of Biochemistry, Kyiv, Ukraine) for assisting the western blot analysis. The authors would also like to thank to Prof. Nina Babel (Center for Translational Medicine and Immune Diagnostics Laboratory, Medical Department I, Marien Hospital Herne, University Hospital of the Ruhr University Bochum, Herne, Germany) for the sodium salt of propionic acid provided and comments regarding its dosage."

"This work was supported by a research grant of the Ministry of Health of Ukraine "Structural and functional changes of neurons of the mediobasal hypothalamus under condition of impaired carbohydrate and lipid metabolism" (state registration number 0119U101229). The authors would like to express their deepest gratitude to Prof. Ludmila Stechenko and Oksana Cryvosheyeva (Department of Histology and Embryology, Bogomolets National Medical University, Kyiv, Ukraine) for their help in performing electron microscopy and describing these data, Prof. Alexandr Grabovoy (Department of Histology and Embryology, Bogomolets National Medical University, Kyiv, Ukraine) for his involvement and valuable advices on immunohistochemical staining of the brain slices, and Dr. Artem Tykhomyrov, Dr. Sci. (Department of Enzyme Chemistry and Biochemistry, Palladin Institute of Biochemistry, Kyiv, Ukraine) for assisting the western blot analysis. The authors would also like to thank to Prof. Nina Babel (Center for Translational Medicine and Immune Diagnostics Laboratory, Medical Department I, Marien Hospital Herne, University Hospital of the Ruhr University Bochum, Herne, Germany) for the sodium salt of propionic acid provided and comments regarding its dosage."