Covalent Allosteric Inhibitors of Akt Generated Using a Click Fragment Approach.

"Conflict of interest The authors declare no conflict of interest."

"The authors are grateful to the Koch group from TU Dortmund for initial molecular modelling work done on potential target compounds. L.v.d.W. is grateful for MSc and PhD scholarship support from the Wilhelm Frank Trust and Stellenbosch University (Harry Crossley bursary); in addition, a Deutscher Akademischer Austauschdienst (DAAD, German Academic Exchange Service) award kindly provided funding for a research visit to Prof. D.R.’s laboratories at TU Dortmund. W.A.L.v.O. is grateful for research funding by the South African Medical Research Council (MRC SIR Grant number 292265) and the National Research Foundation of South Africa (NRF Grant number 93528). Research reported in this publication was supported by the South African MRC under a Self‐Initiated Research grant. The views and opinions expressed are those of the author(s) and do not necessarily represent the official views of the SA MRC. This work was co‐funded by the German Federal Ministry for Education and Research (e:Med, Grant No. BMBF 01ZX1901B), the German federal state North Rhine‐Westphalia (NRW) and the European Union (European Regional Development Fund: Investing In Your Future) (EFRE‐0200479, EFRE‐0400199) Drug Discovery Hub Dortmund (DDHD) and KomIT. Open Access funding enabled and organized by Projekt DEAL."