Characterisation of the Circulating Transcriptomic Landscape in Inflammatory Bowel Disease Provides Evidence for Dysregulation of Multiple Transcription Factors Including NFE2, SPI1, CEBPB, and IRF2.

Publication Year: 2022

DOI:
10.1093/ecco-jcc/jjac033

PMCID:
PMC9426667

PMID:
35212366

Journal Information

Full Title: J Crohns Colitis

Abbreviation: J Crohns Colitis

Country: Unknown

Publisher: Unknown

Language: N/A

Publication Details

Subject Category: Gastroenterology

Available in Europe PMC: Yes

Available in PMC: Yes

PDF Available: No

Transparency Score
4/6
66.7% Transparent
Transparency Indicators
Click on green indicators to view evidence text
Core Indicators
Evidence found in paper:

"the data underlying this article are available in arrayexpress (accession e-mtab-11349)."

Code Sharing
Evidence found in paper:

"Conflict of Interest JKN reports personal fees from Norsa Pharma, a grant from Biocodex Microbiota Foundation, and non-financial support from Nutricia outside of the submitted work. RK has served as a speaker for Ferring and has received support for research from IBD-Character [EU FP7 2858546]. DB has received personal fees as speaker and/or advisory board member for Ferring, Janssen, Pfizer, and Takeda. JW reports personal fees and non-financial support from Biocodex, BGP Products, Chiesi, Hipp, Humana, Mead Johnson Nutrition, Merck Sharp & Dohme, Nestle, Norsa Pharma, Nutricia, Roche, Sequoia Pharmaceuticals, and Vitis Pharma, outside of the submitted work, and also grants, personal fees, and non-financial support from Nutricia Research Foundation Poland, also outside of the submitted work. JJH has received personal fees as speaker, consultant, and/or advisory board member for AbbVie, Aqilion AB, Celgene, Celltrion, Dr Falk Pharma and the Falk Foundation, Ferring, Hospira, Janssen, MEDA, Medivir, MSD, Olink Proteomics, Pfizer, Prometheus Laboratories, Sandoz/Novartis, Shire, Takeda, Thermo Fisher Scientific, Tillotts Pharma, Vifor Pharma, UCB, and has received grant support from Janssen, MSD, and Takeda, outside of the submitted work. JS has served as a speaker, a consultant, and an advisory board member for MSD, Ferring, Abbvie, and Shire, a consultant with Takeda, has received speaking fees from MSD, travel support from Shire, and has received research funding from Abbvie, Wellcome, CSO, MRC, and the EC grant IBDBIOM."

Evidence found in paper:

"Funding This work was supported by the European Union’s Seventh Framework Programme [FP7] grant IBD Character [2858546] and the Polish National Science Centre [2017/25/B/NZ5/02783 to JW]."

Protocol Registration
Open Access
Paper is freely available to read
Additional Indicators
Replication
Novelty Statement
Assessment Info

Tool: rtransparent

OST Version: N/A

Last Updated: Aug 05, 2025