Muscle hypertrophic effect of inhaled beta₂ -agonist is associated with augmented insulin-stimulated whole-body glucose disposal in young men.

"Competing interests The authors declare that there are no relationships or activities that might bias, or be perceived to bias, their work."

"Funding The study was funded by the Danish Ministry of Culture. The study funder was not involved in the design of the study; the collection, analysis, and interpretation of data; writing the report; and did not impose any restrictions regarding the publication of the report."

"The study was part of a larger study (Jessen et al. ) and was designed as a randomized, placebo‐controlled, double‐blinded parallel study (Fig. ). The present study included a subgroup that underwent assessment of insulin‐stimulated whole‐body glucose disposal and body composition, and had muscle and adipose tissue biopsies taken. In this subgroup analysis, the main outcome measure was insulin‐stimulated whole‐body glucose disposal estimated by glucose infusion rate during the final 20 min of a 2 h hyperinsulinaemic‐euglycaemic clamp. The study adhered to the 2013 Helsinki Declaration and was approved by the ethics committee of Copenhagen, Denmark (H‐4‐2014‐002), and registered at Clinicaltrials.gov (NCT02557581). Subjects provided oral and written informed consent before inclusion in the study."