Sofosbuvir and risk of estimated glomerular filtration rate decline or end-stage renal disease in patients with renal impairment.

"6 CONFLICTS OF INTEREST Author: Conflicts of Interest (Research grants, advisory boards, speaker, consultant, other [please specify] OR none). Mark Sulkowski: Ad hoc advisory board: Gilead, Abbvie, Arbutus, Assembly Bio; ImmunoCore, Biomarin. Research (paid to JHU): Gilead, AbbVie, Assembly, Arbutus. DSMB: Gilead. Massimo Colombo: Ad hoc Advisory Board: Merck, Roche, Novartis, Bayer, BMS, Gilead, Tibotec, Vertex, Janssen Cilag, Achillion, Lundbeck, GSK, GenSpera, AbbVie, Alfa Wasserman, Intercept, Target HCC, COST, IDMC Exelixis. Speaking and Teaching: Tibotec, Roche, Novartis, Bayer, BMS, Gilead, Vertex, Merck, Janssen, AbbVie. Francois Durand: None. K. Rajender Reddy: Ad hoc Advisory Board: Mallinckrodt, Gilead, Merck. Research grants (paid to the University of Pennsylvania): Gilead, Merck, BMS, Intercept, Sequana, Grifols, Exalenz, HepQuant, Mallinckrodt. Eric Lawitz: Advisor and Speaker: AbbVie, Gilead. Research and Grant Support: 89Bio, Allergan Inc, Akero Therapeutics, Assembly Bioscoences, Astrazeneca, Axcella Health, Bristol‐Myers Squibb, Boeringer Ingelheim, Celgene Corp, Durect Corporation, Eli Lilly and Company, Elobix, Enanta Pharmaceuticals, Enyo, Galmed Pharmaceuticals, Genfit, Gilead, Hanmi Pharmaceuticals, Intercept Pharmaceuticals, Madrigal Pharmaceuticals, Novartis, Novo Nordisk, Octeta Therapeutics, Poxel, Roche Pharmaceuticals, Viking, Zydus. Marc Bourlière: Advisory Board and speaker: Roche, AbbVie, Gilead, Janssen, Intercept, MSD. Meghan E. Sise: Research funding from Abbvie, Gilead, Merck, EMD Serono. Scientific advisory board member: Gilead, Abbvie. Scientific consultant to Bioporto. The following authors are employees of Gilead Sciences and may hold stock interest in the company: Laura E. Telep, Nelson Cheinquer, Stacey Scherbakovsky, Liyun Ni, Lindsey Force, Heribert Ramroth, Anuj Gaggar, Anand P. Chokkalingam."

"This study was funded by Gilead Sciences, Inc. 10.13039/100005564"