rs2671655 single nucleotide polymorphism modulates the risk for gastric cancer in Helicobacter pylori-infected individuals: a genome-wide association study in the Korean population.

"Declarations Conflict of interestThe authors have no conflicts of interest to declare. Conflict of interest The authors have no conflicts of interest to declare."

"Funding This work was supported by Grant Nos. 06-2019-001 and 02-2020-041 from the research fund of Seoul National University Bundang Hospital."

"This study consecutively incorporated a total of 1216 subjects (610 GC patients and 606 controls) registered at SNUBH. Most of the controls had undergone standard esophagogastroduodenoscopy as part of screening program for premalignant gastric mucosal lesions or GC. The subjects were enrolled as controls when esophagogastroduodenoscopy results showed no evidence of GC, dysplasia, mucosa-associated lymphoid tissue lymphoma, or esophageal cancer. All cases were identified as gastric adenocarcinomas histologically after surgery or endoscopic therapy. All subjects who were 26–80 years of age provided informed consent and were asked to complete a questionnaire under the supervision of a well-trained interviewer. The questionnaire included questions regarding demographic data (age, sex, and current and childhood residences), socioeconomic data (smoking, monthly income, and education level), dietary data (salty and spicy food diet), and history of H. pylori eradication therapy. The study protocol was approved by the Ethical Committee at SNUBH (IRB No. B-1610-366-303). In addition, this study was registered at ClinicalTrials.gov (NCT03486574; date of study start: December 7, 2016; date of primary completion: December 31, 2022 [Anticipated])."