CHIKV strains Brazil (wt) and Ross (lab-adapted) differ with regard to cell host range and antiviral sensitivity and show CPE in human glioblastoma cell lines U138 and U251.

"Declarations Conflict of interestThe authors declare no conflict of interest. The authors declare that there is no financial or personal relationship with other people or organisations that could inappropriately influence the work. Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by Bundeswehr Joint Medical Service or any other governmental institutions. Ethical approvalAll human cell lines used in this study are commercially available and their origin have been stated in the Materials and Methods section. A wt CHIKV was isolated from a diagnostic sample. No patient metadata was collected. No studies with human participants were conducted. Patient consent was obtained according to the national rules for the collection and prior to performing the diagnostic investigation. Conflict of interest The authors declare no conflict of interest. The authors declare that there is no financial or personal relationship with other people or organisations that could inappropriately influence the work. Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by Bundeswehr Joint Medical Service or any other governmental institutions."

"This work was funded by the Bundeswehr Medical Service’s Biodefence research programme and the DZIF TI 07.003 MD Programme-Hucke of the German Center for Infection Research (DZIF), as well as the Zoonoses Sequencing Network BMBF-ZooSeq (01KI1905A). Special thanks go to Dr. Ruth Brack-Werner of the Helmhotz Institute in Munich for a loan of the human glioblastoma cell lines U138 and U251."