Reviewing findings on the polypeptide sequence of the SARS-CoV-2 S-protein to discuss the origins of the virus.

"table 1 [ comment ] viral strain name source accession submission date doi mers-related coronavirus genbank anf29184 1 30-04-2017 10 1093/infdis/jiw236 sars-cov-2_wiv04 gisaid epi_isl_402124 11-01-2020 10 1038/s41586-020-2012-7 sars-cov-2 isolate wuhan-hu-1 genbank qhd43416 1 18-03-2020 10 1038/s41586-020-2012-7 pangolin-cov vipr/genbank qia48614 1 23-04-2020 10 1016/j cub 2020 03 022 pangolin-cov vipr/genbank qiq54048 1 23-04-2020 10 1016/j cub 2020 03 022 pangolin-cov vipr/genbank qia48632 1 23-04-2020 10 1016/j cub 2020 03 022 pangolin-cov vipr/genbank qia48623 1 23-04-2020 10 1016/j cub 2020 03 022 pangolin-cov vipr/genbank qia48641 1 23-04-2020 10 1016/j cub 2020 03 022 pangolin-cov + genbank mt121216 18-05-2020 10 1371/journal ppat 1008421 pangolin-cov + genbank mt084071 1 23-04-2020 10 1002/bies202000240 pangolin-cov gisaid epi_isl_410538 17-02-2020 10 1038/s41586-020-2169-0 pangolin-cov gisaid epi_isl_410539 17-02-2020 10 1038/s41586-020-2169-0 pangolin-cov gisaid epi_isl_410540 17-02-2020 10 1038/s41586-020-2169-0 pangolin-cov gisaid epi_isl_410541 17-02-2020 10 1038/s41586-020-2169-0 pangolin-cov gisaid epi_isl_410542 17-02-2020 10 1038/s41586-020-2169-0 pangolin-cov gisaid epi_isl_410543 17-02-2020 10 1038/s41586-020-2169-0 bat_ratg13 gisaid epi_isl_402131 24-03-2020 10 1038/s41586-020-2012-7 bat coronavirus-former ratg13 genbank qhr63300 1 24-01-2020 10 1038/s41586-020-2012-7 sars coronavirus bj01 genbank aap30030 1 01-09-2009 10 1016/s1672-0229(03)01017-9 bat sars-like rsshc014 genbank agz48806 1 22-11-2013 10 1038/nature12711 bat sars-like wiv1 genbank agz48828 1 22-11-2013 10 1038/nature12711 bat sars_sl-cov rs3367 genbank agz48818 1 22-11-2013 10 1038/nature12711 recombinant fj211860 1 genbank acj60703 1 31-12-2008 10 1073/pnas0808116105 former bat-cov_zc45_avp78031 1 genbank avp78031 1 28-03-2018 10 1038/s41426-018-0155-5 bat-sl-covzc45 genbank avp78031 1 20-05-2020 10 1038/s41426-018-0155-5 former bat-cov_zxc21_avp78042 1 genbank avp78042 1 28-03-2018 10 1038/s41426-018-0155-5 bat sl-covzxc21 genbank avp78042 1 20-05-2020 10 1038/s41426-018-0155-5 recombinant fj211859 1 genbank acj60694 1 26-07-2016 10 1073/pnas0808116105 btrs-betacov/yn2018a genbank qdf43820 1 30-06-2019 10 3389/fmicb 2019 01900 bat sars-like coronavirus genbank ato98181 1 18-12-2017 10 1371/journal ppat 1006698 bat sl-coronavirus rs3262-2 genbank agz48783 1 22-11-2013 10 1038/nature12711 bat sars-like rs4087-2 genbank agz48802 1 22-11-2013 10 1038/nature12711 + deposited sequences of pangolin-covs reporting a full asset of conserved key amino acid residues within the receptor-binding motif of the s-protein of sars-cov-2.; supplementary data: partial alignment among genomes of the coronaviruses ratg13 and sars-cov-2 (accession numbers are available in table 1 ) and the nucleotide sequence of btcov/4991 (genbank kp876546 1) [ ].; however a parallel investigation from a comparative analysis of genomic data generated from the database of the same pangolin sequencing projects used by zhang et al [ ] (srr10168377 and srr10168378 - ncbi bioproject prjna573298 [ ]) identified conservation of the five key amino acid residues and included a sixth conserved residue (s494) [ ].; among the several databases where ratg13 has been deposited [ngdc ( https://bigd big ac cn/ ) accession number: gwhabkp00000000 released 30-01-2020; gisaid ( gisaid org ) accession number: epi_isl_402131 submitted 24-01-2020 collected on 24-07-2013 (date more recently updated since 24 march 2013); genbank ( https://www ncbi nlm nih gov/ ) accession number: mn996532 1 submitted from 29 january 2020 to 24 march 2020 after several revisions] no evidence is documented about the submission of this viral genome earlier than 2020.; the only evidence relates from a partial sequence of a bat coronavirus reported in 2016 and isolated in 2013 from bat feces sampled in an abandoned mine of mojiang (yunnan county china) named btcov/4991 (genbank kp876546 1) [ ] that shows100% identity with a codifying orf for the rna-dependent rna-polymerase (rdrp) of ratg13 [ ]."

"Financial & competing interests disclosure: This investigation was undertaken in the course of the FORMAS Swedish Research Council project no. 2018-00891, title: “Kontroll av skadeinsekter på frukt genom att inrikta sig på”. The author has no other relevant affiliations or financial involvement with any organization or entity with a financial interest or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.: No writing assistance was utilized in the production of this manuscript."

"Financial & competing interests disclosure: This investigation was undertaken in the course of the FORMAS Swedish Research Council project no. 2018-00891, title: “Kontroll av skadeinsekter på frukt genom att inrikta sig på”. The author has no other relevant affiliations or financial involvement with any organization or entity with a financial interest or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.: No writing assistance was utilized in the production of this manuscript."