Review article: rethinking the "ladder" approach to reflux-like symptom management in the era of PPI "resistance" - a multidisciplinary perspective.

"Declaration of personal interests: All authors attended the online workshops organised and funded by Reckitt Benckiser Healthcare Ltd. Pali Hungin has served as a consultant for Sandoz and Chair of Rome IV Primary care committee. Carmelo Scarpignato has served as a consultant for Alfasigma, Dompé Farmaceutici, Shionogi and Biofarma Group. Jean Muris and Maura Corsetti have no further disclosures to declare. Juan Mendive has participated in educational activities funded by Reckitt Benckiser Healthcare Ltd. Foteini Anastasiou is a member of the Programme for NASH in Primary Health Care at the University of Crete, funded by Gilead. Laurie Keefer has served as a consultant for Abbvie and Eli Lilly, is cofounder and owns stocks and shares in Trellus Health and is on the Board of Directors for the Rome Foundation. Peter JK has served as a consultant for Ironwood, Reckitt and Johnson & Johnson."

"Funding informationThe series of workshops on which this article is based were organised and funded by Reckitt Benckiser Healthcare Ltd. Editorial assistance was provided by Lisa O’Rourke PhD of Lumanity, UK, and funded by Reckitt Benckiser Healthcare Ltd."