Neutral sphingomyelinase 2 inhibition attenuates extracellular vesicle release and improves neurobehavioral deficits in murine HIV.

"nucleic acid sequencing data have been deposited with the gene expression omnibus accession gse182743."

"Declaration of Competing Interest: Authors BSS, AGT, and NJH are listed as inventors in patent applications filed by Johns Hopkins Technology Ventures covering novel compositions of nSMase2 inhibitors, including PDDC, and their utility. This arrangement has been reviewed and approved by the Johns Hopkins University in accordance with its conflict of interest policies. Other authors declare that no conflicts of interest exist."

"We are grateful to Dr. Shinji Sakamoto of the Okayama University and Dr. Haiping Hao of the JHU Microarray Core for their technical assistance. This research was supported by National Institute of Health grants R01 AG063831, R01 AG059799, R01 MH104145, R56 NS119438, P30 MH075673, K01 AT010984, R01 DA052272, R01 MH110246, R01 DA040390, and a grant from the Tau Consortium and Alzheimer’s Association (T-PEP-18-579974C)."