The effects of mandibular advancement appliance therapy on the sequence of jaw-closing muscle activity and respiratory events in individuals with obstructive sleep apnea.

"Declarations Ethics approvalAll procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The study was approved by the Medical Ethics Committee of the Université de Montréal (13–105-CERES-D). ConsentInformed consent was obtained from all individual participants included in the study. Competing interestsThe SomnoDent appliances (SomnoMed, Ontario, Canada) were provided free of charge. SomnoMed had no input in the data analyses and publication of this article. Deshui Li is sponsored by the China scholarship council (CSC). Frank Lobbezoo is a member of the Academic Advisory Boards for GrindCare and Oral Function of Sunstar Suisse S.A. and receives research grants from Sunstar Suisse S.A., SomnoMed, VIVISOL B.V., ResMed, Health Holland, and Airway Management. Ghizlane Aarab is a member of the Academic Advisory Board for Oral Function of Sunstar Suisse S.A. and receives research grants from Sunstar Suisse S.A., SomnoMed, VIVISOL B.V., ResMed, and Health Holland. Gilles J. Lavigne received a Canada Research Chair on Pain, Sleep and Trauma during the realization of the protocol and had no other conflict of interest related to the present work. Patrick Arcache and Nelly Huynh had no conflict of interest. Competing interests The SomnoDent appliances (SomnoMed, Ontario, Canada) were provided free of charge. SomnoMed had no input in the data analyses and publication of this article. Deshui Li is sponsored by the China scholarship council (CSC). Frank Lobbezoo is a member of the Academic Advisory Boards for GrindCare and Oral Function of Sunstar Suisse S.A. and receives research grants from Sunstar Suisse S.A., SomnoMed, VIVISOL B.V., ResMed, Health Holland, and Airway Management. Ghizlane Aarab is a member of the Academic Advisory Board for Oral Function of Sunstar Suisse S.A. and receives research grants from Sunstar Suisse S.A., SomnoMed, VIVISOL B.V., ResMed, and Health Holland. Gilles J. Lavigne received a Canada Research Chair on Pain, Sleep and Trauma during the realization of the protocol and had no other conflict of interest related to the present work. Patrick Arcache and Nelly Huynh had no conflict of interest."

"The authors thank SomnoMed (Ontario, Canada) for supplying free of charge the SomnoDent appliances used in this study. Deshui Li is sponsored by the China Scholarship Council, China; the grant has no role in the conception, design, and execution of this study. Declarations: Ethics approvalAll procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The study was approved by the Medical Ethics Committee of the Université de Montréal (13–105-CERES-D).: ConsentInformed consent was obtained from all individual participants included in the study.: Competing interestsThe SomnoDent appliances (SomnoMed, Ontario, Canada) were provided free of charge. SomnoMed had no input in the data analyses and publication of this article. Deshui Li is sponsored by the China scholarship council (CSC). Frank Lobbezoo is a member of the Academic Advisory Boards for GrindCare and Oral Function of Sunstar Suisse S.A. and receives research grants from Sunstar Suisse S.A., SomnoMed, VIVISOL B.V., ResMed, Health Holland, and Airway Management. Ghizlane Aarab is a member of the Academic Advisory Board for Oral Function of Sunstar Suisse S.A. and receives research grants from Sunstar Suisse S.A., SomnoMed, VIVISOL B.V., ResMed, and Health Holland. Gilles J. Lavigne received a Canada Research Chair on Pain, Sleep and Trauma during the realization of the protocol and had no other conflict of interest related to the present work. Patrick Arcache and Nelly Huynh had no conflict of interest. Competing interests: The SomnoDent appliances (SomnoMed, Ontario, Canada) were provided free of charge. SomnoMed had no input in the data analyses and publication of this article. Deshui Li is sponsored by the China scholarship council (CSC). Frank Lobbezoo is a member of the Academic Advisory Boards for GrindCare and Oral Function of Sunstar Suisse S.A. and receives research grants from Sunstar Suisse S.A., SomnoMed, VIVISOL B.V., ResMed, Health Holland, and Airway Management. Ghizlane Aarab is a member of the Academic Advisory Board for Oral Function of Sunstar Suisse S.A. and receives research grants from Sunstar Suisse S.A., SomnoMed, VIVISOL B.V., ResMed, and Health Holland. Gilles J. Lavigne received a Canada Research Chair on Pain, Sleep and Trauma during the realization of the protocol and had no other conflict of interest related to the present work. Patrick Arcache and Nelly Huynh had no conflict of interest."

"Trial registration www.clinicaltrials.gov (NCT02011425); December 13, 2013."