Spirooxindol-1,3-oxazine Alkaloids: Highly Potent and Selective Antitumor Agents Evolved from Iterative Structure Optimization.

"Conflict of interest The authors declare no conflict of interest."

"Annika Eichhorst is grateful for a Ph.D. scholarship of the Landesgraduiertenförderung, University of Rostock, State of Mecklenburg‐Vorpommern, Germany. Le Thi Huyen thanks the “RoHan” program between the University of Rostock and Vietnam National University ‐ Hanoi University of Science for a research scholarship, which was funded by the German Academic Exchange Service (DAAD, project no. 57315854) and the Federal Ministry for Economic Cooperation and Development (BMZ) inside the framework “SDG Bilateral Graduate school program”. We would further like to thank Michael Müller and Wendy Bergmann (Department of Core Facility for Cell Sorting and Cell Analysis, Rostock University Medical Center, Germany) for the possibility of Flow Cytometry device usage and technical support. We also thank Dipl.‐Biol. Beate Wiebeck for evaluating the morphological characterization results. Open Access funding enabled and organized by Projekt DEAL."