3D Lung-on-Chip Model Based on Biomimetically Microcurved Culture Membranes.

"The authors declare the following competing financial interest(s): R.T. and S.G. are founders, shareholders, and managing directors of the company 300MICRONS GmbH active in the field of 3D cell culture solutions."

"The following financial support is acknowledged: D. Baptista, S.v.R., T.P., A.A.P., D.S., R.J.R., P.S.H., and R.T., the Lung Foundation Netherlands (project “Microengineered 3D analogues of alveolar tissue for lung regeneration”; no. 6.1.14.010); D. Baptista, L.M.T., and C.v.B., the European Union/Horizon 2020 European Research Council Advanced Grant (project “ORCHESTRATE – Building complex life through self-organization: from organ to organism”; ID 694801); Z.T.B., P.H., S.G., and R.T., the European Union/Interreg Flanders-The Netherlands (project “Biomat on microfluidic chip”, no. 0433); J.K., A.C., S.G., and R.T., RegMed XB (REGenerative MEDicine crossing Borders) powered by Top Sector Life Sciences & Health (Health ∼ Holland); R.J.R. and R.T., The Netherlands Organisation for Health Research and Development (ZonMw)/COVID-19 MKMD Programme (project “Employing a physiological microfluidic lung bioreactor to improve understanding of SARS-CoV2 biology and testing of therapeutics”; no. 114025011); A.C., C.v.B., P.H., S.G., and R.T., the Dutch province of Limburg (program “Limburg INvesteert in haar Kenniseconomie/LINK”; nos. SAS-2014-00837 and SAS-2018-02477); A.C., C.v.B., P.H., S.G., and R.T., The Netherlands Organization for Scientific Research (NWO)/Gravitation program (project “Materials-driven regeneration: Regenerating tissue and organ function with intelligent, life-like materials”; no. 024.003.013). Author Contributions: ○ P.H., S.G., and R.T. contributed equally to this paper. D. Baptista: formal analysis; investigation; methodology; validation; visualization; writing, original draft preparation; writing, review and editing. L.M.T.: methodology; supervision; writing, review and editing. D. Barata: investigation; writing, review and editing. Z.T.B.: validation; writing, review and editing. J.K.: investigation; writing–review and editing. S.v.R.: writing, review and editing. T.P.: writing, review and editing. A.A.P.: funding acquisition; writing, review and editing. D.S.: funding acquisition; writing, review and editing. R.J.R.: funding acquisition; validation; writing, review and editing. P.S.H.: funding acquisition; validation; writing, review and editing. A.C.: writing, review and editing. C.v.B.: writing, review and editing. P.H.: writing, review and editing. S.G.: conceptualization; methodology; supervision; writing, review and editing. R.T.: conceptualization; funding acquisition; methodology; supervision; validation; writing, original draft preparation; writing, review and editing."