F18-FDG PET/CT imaging early predicts pathologic complete response to induction chemoimmunotherapy of locally advanced head and neck cancer: preliminary single-center analysis of the checkrad-cd8 trial.

"Declarations Conflict of interestM.B. conflict of interest with Novartis (travel expenses); Bayer (advisory role, honoraria); SIRTEX (travel expenses). J.H. has no conflict of interest. M.E. conflict of interest with Diaceutics (employment, honoraria, advisory role, speakers’ bureau, travel expenses); AstraZeneca (honoraria, advisory role, speakers’ bureau, travel expenses); Roche (honoraria, travel expenses); MSD (honoraria, speakers’ bureau); GenomicHealth (honoraria, advisory role, speakers bureau, travel expenses); Astellas (honoraria, speakers’ bureau); Janssen-Cilag (honoraria, advisory role, research funding, travel expenses); Stratifyer (research funding, patents). D.S. has no conflict of interest. A.O.G. has no conflict of interest. S.M. has no conflict of interest. S.R. conflict of interest with AstraZeneca (research funding); MSD (research funding). U.S.G. conflict of interest with AstraZeneca (advisory role, research funding); BMS (advisory role); MSD (research funding); Sennewald Medizintechnik (travel expenses). J.G. has no conflict of interest. I.T. has no conflict of interest. M.G.H. conflict of interest with Roche (stock, honoraria); Varian (stock); Sanofi (honoraria); AstraZeneca (honoraria, travel expenses); BMS (honoraria, advisory role); MSD (honoraria, advisory role); Merck Serono (honoraria); Celgene (honoraria). G.K. conflict of interest with BMS (advisory role); Lilly (advisory role); Roche (advisory role). J.D. has no conflict of interest. B.T. conflict of interest with BMS (honoraria, advisory role, travel expenses); Merck Serono (honoraria, advisory role); MSD (travel expenses). A.H. conflict of interest with BMS (honoraria, advisory role); MSD (honoraria, advisory role); Roche (honoraria, advisory role, research funding); AstraZeneca (honoraria, advisory role, research funding); Boehringer Ingelheim (honoraria); Abbvie (honoraria); Cepheid (advisory role, research funding); Quiagen (advisory role); Janssen-Cilag (honoraria, advisory role, research funding); Ipsen (honoraria, advisory role); NanoString Technologies (advisory role, research funding, expert testimony); Illumina (advisory role); 3DHistech (advisory role); Diaceutics (advisory role); BioNTech (research funding). H.I. has no conflict of interest. T.K. conflict of interest with Siemens Healthineers (advisory role, honoraria, speakers’ bureau, travel expenses, research funding). R.F. conflict of interest with MSD (honoraria, advisory role, research funding, travel expenses); Fresenius (honoraria); BrainLab (honoraria); AstraZeneca (honoraria, advisory role, research funding, travel expenses); Merck Serono (advisory role, research funding, travel expenses); Novocure (advisory role, speakers’ bureau, research funding); Sennewald (speakers’ bureau, travel expenses). The other authors declare no conflicts of interest. M.H. conflict of interest with Merck Serono (advisory role, speakers’ bureau, honoraria, travel expenses, research funding); MSD (advisory role, speakers’ bureau, travel expenses, research funding); AstraZeneca (research funding); Novartis (research funding); BMS (advisory role, honoraria, speakers’ bureau); Teva (travel expenses). S.S. conflict of interest with Strycker (stock); Varian (stock); Abbot (stock); Crispr Techn. (stock); Pfitzer (stock); Merck Serono (stock); Symrise (stock); Ortho (honoraria, advisory role, speakers’ bureau, research funding, travel expenses); PharmaMar (speakers’ bureau, travel expenses); Haema (speakers’ bureau). Ethical approvalThe trial was registered with ClinicalTrials.gov (identifier: NCT03426657). The institutional review board at the Friedrich-Alexander-Universität Erlangen-Nürnberg (number: 131_18 Az) approved the trial. All patients gave written informed consent to the study and to publication. The trial was funded by AstraZeneca (ESR-16-12356) and was conducted as investigator sponsored trial. The study was carried out in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments. Conflict of interest M.B. conflict of interest with Novartis (travel expenses); Bayer (advisory role, honoraria); SIRTEX (travel expenses). J.H. has no conflict of interest. M.E. conflict of interest with Diaceutics (employment, honoraria, advisory role, speakers’ bureau, travel expenses); AstraZeneca (honoraria, advisory role, speakers’ bureau, travel expenses); Roche (honoraria, travel expenses); MSD (honoraria, speakers’ bureau); GenomicHealth (honoraria, advisory role, speakers bureau, travel expenses); Astellas (honoraria, speakers’ bureau); Janssen-Cilag (honoraria, advisory role, research funding, travel expenses); Stratifyer (research funding, patents). D.S. has no conflict of interest. A.O.G. has no conflict of interest. S.M. has no conflict of interest. S.R. conflict of interest with AstraZeneca (research funding); MSD (research funding). U.S.G. conflict of interest with AstraZeneca (advisory role, research funding); BMS (advisory role); MSD (research funding); Sennewald Medizintechnik (travel expenses). J.G. has no conflict of interest. I.T. has no conflict of interest. M.G.H. conflict of interest with Roche (stock, honoraria); Varian (stock); Sanofi (honoraria); AstraZeneca (honoraria, travel expenses); BMS (honoraria, advisory role); MSD (honoraria, advisory role); Merck Serono (honoraria); Celgene (honoraria). G.K. conflict of interest with BMS (advisory role); Lilly (advisory role); Roche (advisory role). J.D. has no conflict of interest. B.T. conflict of interest with BMS (honoraria, advisory role, travel expenses); Merck Serono (honoraria, advisory role); MSD (travel expenses). A.H. conflict of interest with BMS (honoraria, advisory role); MSD (honoraria, advisory role); Roche (honoraria, advisory role, research funding); AstraZeneca (honoraria, advisory role, research funding); Boehringer Ingelheim (honoraria); Abbvie (honoraria); Cepheid (advisory role, research funding); Quiagen (advisory role); Janssen-Cilag (honoraria, advisory role, research funding); Ipsen (honoraria, advisory role); NanoString Technologies (advisory role, research funding, expert testimony); Illumina (advisory role); 3DHistech (advisory role); Diaceutics (advisory role); BioNTech (research funding). H.I. has no conflict of interest. T.K. conflict of interest with Siemens Healthineers (advisory role, honoraria, speakers’ bureau, travel expenses, research funding). R.F. conflict of interest with MSD (honoraria, advisory role, research funding, travel expenses); Fresenius (honoraria); BrainLab (honoraria); AstraZeneca (honoraria, advisory role, research funding, travel expenses); Merck Serono (advisory role, research funding, travel expenses); Novocure (advisory role, speakers’ bureau, research funding); Sennewald (speakers’ bureau, travel expenses). The other authors declare no conflicts of interest. M.H. conflict of interest with Merck Serono (advisory role, speakers’ bureau, honoraria, travel expenses, research funding); MSD (advisory role, speakers’ bureau, travel expenses, research funding); AstraZeneca (research funding); Novartis (research funding); BMS (advisory role, honoraria, speakers’ bureau); Teva (travel expenses). S.S. conflict of interest with Strycker (stock); Varian (stock); Abbot (stock); Crispr Techn. (stock); Pfitzer (stock); Merck Serono (stock); Symrise (stock); Ortho (honoraria, advisory role, speakers’ bureau, research funding, travel expenses); PharmaMar (speakers’ bureau, travel expenses); Haema (speakers’ bureau)."

"Funding Open Access funding enabled and organized by Projekt DEAL. The trial was funded by AstraZeneca (ESR-16-12356) and was conducted as investigator sponsored trial."

"The trial was registered with ClinicalTrials.gov (identifier: NCT03426657). The local review board (number: 131_18 Az) approved the trial. All patients gave written informed consent. The trial was funded by AstraZeneca (ESR-16-12,356) and was conducted as investigator sponsored trial. Declarations: Conflict of interestM.B. conflict of interest with Novartis (travel expenses); Bayer (advisory role, honoraria); SIRTEX (travel expenses). J.H. has no conflict of interest. M.E. conflict of interest with Diaceutics (employment, honoraria, advisory role, speakers’ bureau, travel expenses); AstraZeneca (honoraria, advisory role, speakers’ bureau, travel expenses); Roche (honoraria, travel expenses); MSD (honoraria, speakers’ bureau); GenomicHealth (honoraria, advisory role, speakers bureau, travel expenses); Astellas (honoraria, speakers’ bureau); Janssen-Cilag (honoraria, advisory role, research funding, travel expenses); Stratifyer (research funding, patents). D.S. has no conflict of interest. A.O.G. has no conflict of interest. S.M. has no conflict of interest. S.R. conflict of interest with AstraZeneca (research funding); MSD (research funding). U.S.G. conflict of interest with AstraZeneca (advisory role, research funding); BMS (advisory role); MSD (research funding); Sennewald Medizintechnik (travel expenses). J.G. has no conflict of interest. I.T. has no conflict of interest. M.G.H. conflict of interest with Roche (stock, honoraria); Varian (stock); Sanofi (honoraria); AstraZeneca (honoraria, travel expenses); BMS (honoraria, advisory role); MSD (honoraria, advisory role); Merck Serono (honoraria); Celgene (honoraria). G.K. conflict of interest with BMS (advisory role); Lilly (advisory role); Roche (advisory role). J.D. has no conflict of interest. B.T. conflict of interest with BMS (honoraria, advisory role, travel expenses); Merck Serono (honoraria, advisory role); MSD (travel expenses). A.H. conflict of interest with BMS (honoraria, advisory role); MSD (honoraria, advisory role); Roche (honoraria, advisory role, research funding); AstraZeneca (honoraria, advisory role, research funding); Boehringer Ingelheim (honoraria); Abbvie (honoraria); Cepheid (advisory role, research funding); Quiagen (advisory role); Janssen-Cilag (honoraria, advisory role, research funding); Ipsen (honoraria, advisory role); NanoString Technologies (advisory role, research funding, expert testimony); Illumina (advisory role); 3DHistech (advisory role); Diaceutics (advisory role); BioNTech (research funding). H.I. has no conflict of interest. T.K. conflict of interest with Siemens Healthineers (advisory role, honoraria, speakers’ bureau, travel expenses, research funding). R.F. conflict of interest with MSD (honoraria, advisory role, research funding, travel expenses); Fresenius (honoraria); BrainLab (honoraria); AstraZeneca (honoraria, advisory role, research funding, travel expenses); Merck Serono (advisory role, research funding, travel expenses); Novocure (advisory role, speakers’ bureau, research funding); Sennewald (speakers’ bureau, travel expenses). The other authors declare no conflicts of interest. M.H. conflict of interest with Merck Serono (advisory role, speakers’ bureau, honoraria, travel expenses, research funding); MSD (advisory role, speakers’ bureau, travel expenses, research funding); AstraZeneca (research funding); Novartis (research funding); BMS (advisory role, honoraria, speakers’ bureau); Teva (travel expenses). S.S. conflict of interest with Strycker (stock); Varian (stock); Abbot (stock); Crispr Techn. (stock); Pfitzer (stock); Merck Serono (stock); Symrise (stock); Ortho (honoraria, advisory role, speakers’ bureau, research funding, travel expenses); PharmaMar (speakers’ bureau, travel expenses); Haema (speakers’ bureau).: Ethical approvalThe trial was registered with ClinicalTrials.gov (identifier: NCT03426657). The institutional review board at the Friedrich-Alexander-Universität Erlangen-Nürnberg (number: 131_18 Az) approved the trial. All patients gave written informed consent to the study and to publication. The trial was funded by AstraZeneca (ESR-16-12356) and was conducted as investigator sponsored trial. The study was carried out in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments. Ethical approval: The trial was registered with ClinicalTrials.gov (identifier: NCT03426657). The institutional review board at the Friedrich-Alexander-Universität Erlangen-Nürnberg (number: 131_18 Az) approved the trial. All patients gave written informed consent to the study and to publication. The trial was funded by AstraZeneca (ESR-16-12356) and was conducted as investigator sponsored trial. The study was carried out in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments."