Immediate versus staged revascularisation of non-culprit arteries in patients with acute coronary syndrome: a systematic review and meta-analysis.

"Conflict of interest P.A. Vriesendorp, J.M. Wilschut, R. Diletti, J. Daemen, I. Kardys, F. Zijlstra, N.M. Van Mieghem, J. Bennett, G. Esposito, M. Sabate and W.K. den Dekker declare that they have no competing interests."

"The protocol for this systematic review and meta-analysis was developed and registered in the PROSPERO database (CRD42019124604) and was reported in accordance with the PRISMA statement guidelines []. The search strategy was developed using the main parameters (Table ), and PubMed, EMBASE, Cochrane Library and MEDLINE online databases were searched for publications between 2000 and 1 April 2020. An example of the search strategy for EMBASE can be found in Table S1 (Electronic Supplementary Material). Pre-defined inclusion criteria were based on the main parameters and included head-to-head comparisons of immediate revascularisation of non-culprit arteries with staged revascularisation in patients with ACS and MVD. Both RCTs and non-randomised comparisons were included. The records obtained were assessed on the title and abstract and were excluded if one of the following was applicable: case reports, observational studies without a comparison group, reviews, meta-analyses, lack of relevant outcomes or study question and conference abstracts. Selected full text records were analysed by two independent reviewers (WKD and PAV) to determine if the inclusion criteria were fulfilled. Any disagreements were resolved by consensus. If > 1 publication was based on the same cohort or population and reported the same outcomes, only the most recent or comprehensive publication was included. In addition, a manual reference search of relevant literature was performed to ensure completeness."